Open Access

What is

OPEN ACCESS

Open Access means free and barrier-free access to scientific knowledge, as stated in the Berlin Declaration.

“Our mission of disseminating knowledge is incomplete if information is not made widely and readily available to society. We need to support new possibilities for disseminating knowledge, not just the paradigm of open access via the Internet. We define open access as an extended source of human knowledge and cultural heritage that has been validated by the scientific community.”

The principle of open access responds to the high constitutional values of promoting the development of culture and scientific and technical research, as well as protecting academic freedom.

In particular, it aims to:

  • enhance the diffusion of scientific research on an international scale
  • compress the rate of duplication of scientific studies
  • strengthen interdisciplinary research, the transfer of knowledge to businesses and transparency towards citizens
  • make the use of scientific contributions for educational purposes more efficient
  • guarantee the preservation of scientific production over time

“The advantages of Open Access, in terms of greater circulation and sharing of knowledge and their impact on an economic and social level, are recognized and supported by the policies of the European Commission, by international and national research funding agencies, by regulatory provisions national, as well as numerous declarations of principle by international organizations and bodies.

Attachments

Berlin Declaration
Heal Italia Regolamento Open Science

Contacts

healitalia@gmail.com

Open Research

What is

OPEN RESEARCH

Open access to publications, as well as the Open Research Data Pilot (ORDP), has been a key policy throughout Horizon 2020, the Framework Program for Research and Innovation. Under the new Framework Programme Horizon Europe (2021-2027) the Commission intends to further strengthen aspects of open science, also imposing open access to research data as a priority choice, but always according to the principle “as open as possible, as closed as necessary”.

Open science is a strategic priority for the European Commission and the challenge for Europe is to ensure that open science becomes the modus operandi for all researchers.
Open science is about sharing knowledge, data and tools in the research and innovation (R&I) process as quickly as possible, in open collaboration with all relevant knowledge actors, including academia, industry, public authorities, end users, citizens and society in general.

Open science helps improve the quality, efficiency and impact of R&I, increase responsiveness to the challenges faced by society and increase society’s trust in the scientific system.

Since 2016, the Commission has organized its open science policy according to eight “ambitions”: 

  • Open Data: FAIR (Findable, Accessible, Interoperable and Reusable data) and open data sharing should become the default for EU-funded scientific research results.
  • European Open Science Cloud (EOSC): a “federated research data infrastructure ecosystem” that will enable the scientific community to share and process publicly funded research results and data across scientific borders and sectors.
  • Metriche di nuova generazione (New Generation Metrics): new indicators must be developed to complement conventional indicators for research quality and impact, so as to reward open science practices.
  • Future of academic communication (Scholarly communication): all peer-reviewed scientific publications should be freely accessible and early sharing of different types of research results should be encouraged.
  • Rewards: research career evaluation systems should fully recognize open science activities.
  • Integrità della ricerca (Research integrity): all publicly funded research in the EU should comply with agreed research integrity standards.
  • Istruzione e competenze (Education and skills): all scientists in Europe should have the necessary skills and support to apply open scientific research practices.
  • Scienza dei cittadini (Citizen science): citizens can make a significant contribution and be recognized as valid producers of European scientific knowledge.

Contacts

healitalia@gmail.com

Open Science

What is

OPEN SCIENCE

Open Science is “doing science” so that other researchers can collaborate and contribute; where data, lab notes and other processes are made available, under licenses that allow the reuse, redistribution and reproduction of the research and its methods.

“Open science is an approach to the scientific process based on collaboration, open and timely sharing of results, ways of disseminating knowledge based on networked digital technologies and transparent methods of validation and evaluation of research products. Open science increases the effectiveness of collaboration and the reproducibility of research results. It increases the collaborative potential with the possibility of accessing data and reusing them for new analyses, including interdisciplinary ones, and for scientific teaching, as well as the usability of scientific knowledge, in a transparent way, for the benefit of society.”

Ministero dell’Università e della Ricerca, Piano Nazionale per la Scienza Aperta 2021-2027

According to the European Commission, Open Science is:

  • share methodologies, knowledge, processes and tools in an open and transparent way, from the early stages of the scientific discovery process
  • transparency in the experimental methodology, in the observation of phenomena and in the collection of data
  • reliability and public reusability of scientific data and research products
  • public accessibility and transparency of scientific communication processes
  • use and sharing of web-based tools to facilitate scientific collaboration

“Open science is defined as an inclusive construct that combines various movements and practices aiming to make multilingual scientific knowledge openly available, accessible and reusable for everyone, to increase scientific collaborations and sharing of information for the benefits of science and society, and to open the processes of scientific knowledge creation, evaluation and communication to societal actors beyond the traditional scientific community. It comprises all scientific disciplines and aspects of scholarly practices, including basic and applied sciences, natural and social sciences and the humanities, and it builds on the following key pillars: open scientific knowledge, open science infrastructures, science communication, open engagement of societal actors and open dialogue with other knowledge systems.”

UNESCO Recommendation on Open Science

Contacts

healitalia@gmail.com

Holistic nosology

SPOKE 1

Holistic nosology

From patients to molecules and back: mapping the omic landscape of clinical to molecular environment, to identify, classify, and refine the phenotypes of multifactorial diseases

GENERAL OBJECTIVE

Mapping the omics landscape of clinical to molecular environment, Spoke 1 will define the molecular markers predictors of adverse or protective events underlying the molecular mechanisms of multifactorial diseases, which will offer potential novel therapeutic targets and clusters of prognostic factors.

Referent: Prof. ssa Eleonora Candi
Leader Institution: University of Rome Tor Vergata
Participating entities: ISS, NEUROMED, SAPIENZA, TLS, UNIBO, UNICA, UNIFG, UNIMORE, UNIVPM, UNIVR

SPOKE 1
SPOKE 2
SPOKE 3
SPOKE 4
SPOKE 5
SPOKE 6
SPOKE 7
SPOKE 8

Intelligent health

SPOKE 2

Intelligent health

Health Data Science: Data management and development of advanced methods, algorithms, and machine learning approaches integrating health big data.

GENERAL OBJECTIVE

Through an efficient data management and development of advanced methods, algorithms, and machine learning approaches integrating health big data, Spoke 2 will establish a model of a collaborative data and analysis platform in full compliance with the Italian privacy legislation for enabling the processing of predictive computer models on large volumes of digital heterogeneous data, opening new avenues for modern healthcare and personalized medicine.

Referent: Prof. Stefano Diciotti
Leader Institution: Alma Mater Studiorum University of Bologna
Participating entities: BIREX, ENGINEERING, IFO-IRE, ISS, NEUROMED, SAPIENZA, TOR VERGATA, UNICA, UNICT, UNIMIB, UNIMORE, UNIPI, UNIVR

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Precision diagnostic

SPOKE 4

Precision diagnostic

Precision medicine integrating clinic and imaging biomarkers for a high precise in space and time diagnosis.

GENERAL OBJECTIVE

Implementing the computational tools in the clinical practice supported by the integrated analysis of digital data including bioimaging, omics and data derived from medical devices, performed using computational tools (AI and network medicine), Spoke 4 will deliver new, cost-effective, evidence-based, predictive risk-based and non-invasive diagnostic pathways for faster, earlier, more precise, accessible, and affordable early detection and screening of mono- and polygenic diseases and cancer.

Referente: Prof. Andrea Isidori
Leader Institution: Sapienza University of Rome
Participating entities: S.ORSOLA, TOR VERGATA, UNIBO, UNICA, UNICT, UNIFG, UNIMIB, UNIMORE, UNIPA, UNIPI, UNIVPM, UNIVR

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Next-gen therapeutics

SPOKE 5

Next-gen therapeutics

From silico to bedside: design and validation ofinnovative tailored and personalized therapeutic strategies.

GENERAL OBJECTIVE

Validating new targets and therapeutic effectors, determining the cellular and molecular targets and completing the analysis in pre-clinical settings, spoke 5 will define the drug candidate and drug action mechanisms at the cellular and molecular level, establishing reproducible and quick pipelines for the preclinical validation of innovative therapies against monogenic, polygenic diseases and cancer.

Referent: Prof. Francesca Granucci
Leader Institution: University of Milano-Bicocca
Participating entities: CRO Aviano, ISS, M.NEGRI, NEUROMED, OPELLA, SAPIENZA, SIT, TLS, UNIBO, UNICA, UNICT, UNIMORE, UNIPA, UNIPI, UNIVR

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SPOKE 8

Healthy toolbox

SPOKE 6

Healthy toolbox

Development of innovative devices for precision diagnosis and personalized therapy.

GENERAL OBJECTIVE

Spoke 6 will develop a technological toolbox of devices for applications both in precision diagnostics including biosensors, electronic and optical devices, integrated with microfluidics, and therapy such as robotic systems and development of nanotherapeutic agents for minimally invasive treatment, design and fabrication of strategies to selectively direct a drug towards a specific organ or tissue or cellular system, and to obtain the release/maintenance of the therapeutic agent at the target site for an extended period.

Referent: Prof. Massimo Dominici e Augusto Carlo Bortolotti
Leader Institution: University of Modena and Reggio Emilia
Participating entities: CRO Aviano, UNIBO, UNICA, UNICT, UNIFG, UNIMIB, UNIPA, UNIPI, UNIVR

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Prevention strategies

SPOKE 7

Prevention strategies

Integrated and gender medicine approaches for prevention strategies based on environmental, lifestyle and clinical biometric data

GENERAL OBJECTIVE

Spoke 7 aims at predicting more accurately which prevention strategies/interventions for a particular disease will work in which groups of people and will assist in establishing public health recommendations for specific subgroups based on phenotype, genotype and the exposome. The proposed research aims at identifying determinants of the individual risk to develop diseases with a high impact on the health status of a population, such as cardiovascular, cancer, or endocrine-metabolic diseases

Referent: Prof. Gianluca Moroncini
Leader Institution: Politechnic University of Marche
Participating entities: IFO-IRE, ISS, NEUROMED, SAPIENZA, UNIBO, UNICA, UNICT, UNIFG, UNIMORE

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Clinical exploitation

SPOKE 8

Clinical exploitation

Clinical validation and implementation of innovative predictive, preventive, diagnostic and therapeutic precision medicine approaches, based on established or emerging molecular and clinical phenotyping and AI-driven decision-making protocols.

GENERAL OBJECTIVE

This spoke aims on the clinical validation and implementation of precision medicine approaches, mainly based on data currently available in the participating centers or being generated by the applicants in this Spoke, and with readiness to exchange and apply emerging knowledge by interactions with all other Spokes.

Referent: Prof. Piero Marchetti e Chiara Cremolini
Leader Institution: University of Pisa
Participating entities: IFO-IRE, M.NEGRI, S.ORSOLA, SAPIENZA, TLS, TOR VERGATA, UNIBO, UNICA, UNICT, UNIMIB, UNIMORE, UNIPA, UNIVR, UPMC

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Prediction models

SPOKE 3

Prediction models

Advanced prediction models for prognosis and therapeutic response based on comprehensive data treatment

GENERAL OBJECTIVE

Spoke 3 will develop advanced computational and animal models recapitulating the complex evolution of a cell even following an action of an external agent including compounds and radiation, which will support clinical decisions for the management of patients affected by monogenic and polygenic diseases including those dependent from specific mutations, and cancer, thus avoiding radiation toxicity to resistant patients and reducing the treatment costs.

Referent: Prof. Giorgio Stassi
Leader Institution: University of Palermo
Participating entities: BIREX, IFO-IRE, IOM, ISS, M.NEGRI, SAPIENZA, SIT, TOR VERGATA, UNIBO, UNICA, UNICT, UNIFG, UNIMIB, UNIMORE, UNIPI, UNIVPM

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