Research

Atrial natriuretic peptide (ANP) modulates stress-induced autophagy in endothelial cells
2025 Spoke 1 Cardiovascular diseases Preclinical studies on fundamental disease mechanisms

Maurizio Forte, Simona Marchitti, Flavio di Nonno, Donatella Pietrangelo, Rosita Stanzione, Maria Cotugno, Luca D’Ambrosio, Alessandra D’Amico, Vittoria Cammisotto, Gianmarco Sarto, Erica Rocco, Beatrice Simeone, Sonia Schiavon, Daniele Vecchio, Roberto Carnevale, Salvatore Raffa, Giacomo Frati, Massimo Volpe, Sebastiano Sciarretta, Speranza Rubattu

Decreased circulating IPA levels identify subjects with metabolic comorbidities: A multi-omics study
2024 Spoke 1 Metabolic diseases and systemic inflammation Preclinical studies on fundamental disease mechanisms

Marta Ballanti, Lorenzo Antonetti, Maria Mavilio, Viviana Casagrande, Alessandro Moscatelli, Daniele Pietrucci, Adelaide Teofani , Chiara Internò, Marina Cardellini, Omero Paoluzi, Giovanni Monteleone, Philippe Lefebvre, Bart Staels, Geltrude Mingrone, Rossella Menghini, Massimo Federici

Targeting exhausted cytotoxic T cells through CTLA-4 inhibition promotes elimination of neoplastic cells in human myelofibrosis xenografts
2024 Spoke 1 Oncology and innovative therapies

Lara Tavernari, Sebastiano Rontauroli, Ruggiero Norfo, Margherita Mirabile, Monica Maccaferri, Barbara Mora, Elena Genovese, Sandra Parenti, Chiara Carretta, Elisa Bianchi, Matteo Bertesi, Francesca Pedrazzi, Elena Tenedini, Silvia Martinelli, Maria Teresa Bochicchio, Paola Guglielmelli, Leonardo Potenza, Alessandro Lucchesi, Francesco Passamonti, Enrico Tagliafico, Mario Luppi, Alessandro Maria Vannucchi, Rossella Manfredini

Mitophagy modulation for the treatment of cardiovascular diseases
2024 Spoke 1 Cardiovascular diseases Preclinical studies on fundamental disease mechanisms

Maurizio Forte, Luca D’Ambrosio, Gabriele G. Schiattarella, Nadia Salerno, Marco Alfonso Perrone, Francesco S. Loffredo, Edoardo Bertero, Kalliopi Pilichou, Girolamo Manno, Valentina Valenti, Luigi Spadafora, Marco Bernardi, Beatrice Simeone, Gianmarco Sarto, Giacomo Frati, Cinzia Perrino, Sebastiano Sciarretta, the Italian Society of Cardiology Working Group on Cellular and Molecular Biology of the Heart

The rs11568820 Variant in the Promoter Region of Vitamin D Receptor Gene Is Associated with Clinical Remission in Rheumatoid Arthritis Patients Receiving Tumor Necrosis Factor Inhibitors
2024 Spoke 1 Metabolic diseases and systemic inflammation Rare diseases and genetic disorders

Andrea Latini, Giada De Benedittis, Paola Conigliaro, Chiara Bonini, Chiara Morgante, Maria Iacovantuono, Arianna D’Antonio, Alberto Bergamini, Giuseppe Novelli, Maria Sole Chimenti, Cinzia Ciccacci and Paola Borgiani

An Optimized NGS Workflow Defines Genetically Based Prognostic Categories for Patients with Uveal Melanoma
2025 Spoke 3 Oncology and innovative therapies

Michele Massimino, Elena Tirrò,Stefania Stella, Cristina Tomarchio, Sebastiano Di Bella,Silvia Rita Vitale, Chiara Conti, Marialuisa Puglisi, Rosa Maria Di Crescenzo, Silvia Varricchio, Francesco Merolla, Giuseppe Broggi, Federica Martorana, Alice Turdo, Miriam Gaggianesi, Livia Manzella, Andrea Russo, Giorgio Stassi, Rosario Caltabiano, Stefania Staibano

Biallelic PI4KA Mutations Disrupt B-Cell Metabolism and Cause B-Cell Lymphopenia and Hypogammaglobulinemia
2024 Spoke 3 Rare diseases and genetic disorders

Francesco Saettini, Fabiola Guerra, Mario Mauri, Claire G. Salter, Margaret P. Adam, David Adams, Emma L. Baple, Estibaliz Barredo, Sanil Bhatia, Arndt Borkhardt, Alfredo Brusco, Cristina Bugarin, Clizia Chinello, Andrew H. Crosby, Precilla D’Souza, Vanna Denti, Grazia Fazio, Silvia Giuliani, Hye Sun Kuehn, Hassan Amel, Asha Elmi, Bernice Lo, Federica Malighetti, Giorgia Mandrile, Andrea Martín-Nalda, Heather C. Mefford, Daniele Moratto, Fatemeh Emam Mousavi, Zoe Nelson, Luis González Gutiérrez-Solana, Ellen Macnamara, Vincent Michaud, Melanie O’Leary, Lisa Pagani, Lisa Pavinato, Patricia VVelez Santamaria, Laura Planas-Serra, Manuel Quadri, Miquel Raspall-Chaure, Stefano Rebellato, Sergio D. Rosenzweig, Agathe Roubertie, Dirk Holzinger, Christin Deal, Catherine Walsh Vockley, Angela Maria Savino, Jennifer L.Stoddard, Holm H. Uhlig, Aurora Pujol, Fulvio Magni, Giuseppe Paglia, Gianni Cazzaniga, Rocco Piazza, Matteo Barberis & Andrea Biondi

Thioredoxin-interacting protein (TXNIP) is a substrate of the NEDD4-like E3 ubiquitin-protein ligase WWP1 in cellular redox state regulation of acute myeloid leukemia cells
2024 Spoke 1 Oncology and innovative therapies Preclinical studies on fundamental disease mechanisms

Sara Giovannini, Yanan Li, Rosalba Pecorari, Claudia Fierro, Claudia Fiorilli, Federica Corigliano, Valeria Moriconi, Ji Zhou, Anna De Antoni, Artem Smirnov, Sara Rinalducci, Anna Maria Timperio, Massimiliano Agostini, Jinping Zhang, Yufang Shi, Eleonora Candi, Gerry Melino, Francesca Bernassola

Chromosome 9p trisomy increases stem cells clonogenic potential and fosters T-cell exhaustion in JAK2-mutant myeloproliferative neoplasms
2024 Spoke 1 Oncology and innovative therapies

Chiara Carretta, Sandra Parenti, Matteo Bertesi, Sebastiano Rontauroli, Filippo Badii, Lara Tavernari, Elena Genovese, Marica Malerba, Elisa Papa, Samantha Sperduti, Elena Enzo, Margherita Mirabile, Francesca Pedrazzi, Anita Neroni, Camilla Tombari, Barbara Mora, Margherita Maffioli, Marco Mondini, Marco Brociner, Monica Maccaferri, Elena Tenedini, Silvia Martinelli, Niccolò Bartalucci, Elisa Bianchi, on behalf of MYNERVA (Myeloid NEoplasms Research Venture AIRC)

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