Beatrice Riccò, Giulia Grisendi, Andrea Lo Monaco, Dilia Giuggioli, Enrico Clini, Massimo Dominici
Spoke: Spoke 8
Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in mice
Farooq Syed , Olivia Ballew , Chih-Chun Lee , Jyoti Rana , Preethi Krishnan , Angela Castela , Staci A Weaver , Namratha Shivani Chalasani , Sofia F Thomaidou , Stephane Demine , Garrick Chang , Alexandra Coomans de Brachène ,Maria Ines Alvelos , Lorella Marselli , Kara Orr , Jamie L Felton , Jing Liu 1, Piero Marchetti, Arnaud Zaldumbide , Donalyn Scheuner , Decio L Eizirik , Carmella Evans-Molina.
Concordance of PD-L1 status in primary gastroesophageal adenocarcinoma and matched peritoneal metastases: a single institution study
Massa V, Signorini F, Salani F, Filice ME, Grelli G, Lippolis P, Faviana P, Genovesi V, Santi S, Vivaldi C, Cesario S, Bertolucci A, Cremolini C, Nardini V, Masi G, Ugolini C, Fornaro L.
Prognostic and predictive implications of tumor suppressor gene alterations in non-small cell lung cancer
Sposito M, Belluomini L, Nocini R, Insolda J, Scaglione IM, Menis J, Simbolo M, Lugini A, Buzzacchino F, Verderame F, Spinnato F, Aprile G, Calvetti L, Occhipinti M, Marinelli D, Veccia A, Lombardo F, Soto Parra HJ, Ferraù F, Savastano C, Porta C, Pradelli L, Sicari E, Castellani S, Malapelle U, Passiglia F, Bria E, Pilotto S, Milella M.
Genomic profiling in hepatocellular carcinoma: a real-world retrospective analysis
Salani F, Ponziani FR, Piscaglia F, Malapelle U, Daniele B, Porta C, Pradelli L, De Fiore E, Masi G, Rimassa L, Casadei Gardini A
Characteristics and outcomes of immunotherapy-related liver injury in patients with hepatocellular carcinoma versus other advanced solid tumours
Celsa C, Cabibbo G, Fulgenzi CAM, Scheiner B, D’Alessio A, Manfredi GF, Nishida N, Ang C, Marron TU, Saeed A, Wietharn B, Pinter M, Cheon J, Huang YH, Lee PC, Phen S, Gampa A, Pillai A, Vivaldi C, Salani F, …..
A Misleading Case of NTRK-Rearranged Papillary Thyroid Carcinoma
Francesco Demetrio Lofaro, Dilia Giuggioli, Susanna Bonacorsi, Martina Orlandi, Amelia Spinella, Marco De Pinto, Ottavio Secchi, Clodoveo Ferri, Federica Boraldi
BMP-4 and fetuin A in systemic sclerosis patients with or without calcinosis
Francesco Demetrio Lofaro, Dilia Giuggioli, Susanna Bonacorsi, Martina Orlandi, Amelia Spinella, Marco De Pinto, Ottavio Secchi, Clodoveo Ferri, Federica Boraldi
The importance of body image and aesthetic medicine in systemic sclerosis
Orlandi M, Spinella A, De Pinto M, Sandri G, De Santis G,
Giuggioli D.
Diagnostic capabilities, clinical features, and longitudinal UBA1 clonal dynamics of a nationwide VEXAS cohort
Carmelo Gurnari, Maria Rosaria Pascale, Antonio Vitale, Elisa Diral, Alessandro Tomelleri, Elisa Galossi, Giulia Falconi, Alessandro Bruno, Francesca Crisafulli, Micol Frassi, Chiara Cattaneo, Diego Bertoli, Massimo Bernardi, Annalisa Condorelli, Erika Morsia, Antonella Poloni, Elena Crisà, Daniela Caravelli, Paola Triggianese, Luisa Brussino, Giorgia Battipaglia, Sara Bindoli, Paolo Sfriso, Federico Caroni, Matteo Dragani, Flavia Mallegni, Federica Pilo, Davide Firinu, Antonio Curti, Cristina Papayannidis, Attilio Olivieri, Sharham Kordasti, Francesco Albano, Fabrizio Pane, Pellegrino Musto, Monica Bocchia, Elisabetta Lugli, Massimo Breccia, Marco Frigeni, Lorenzo Dagna, Raffaella Greco, Franco Franceschini, Corrado Campochiaro, Luca Cantarini, Maria Teresa Voso
Performance and clinical utility of two targeted multigene panels for GIST molecular characterization
Nannini M, Astolfi A, Maloberti T, Nigro MC, Gozzellino L, Costa A, Pirini MG, De Leo A, Grillini M, Altimari A, Del Gaudio M, Vincenzi B, Fumagalli E, Brunello A, Grignani G, Aliberti S, Ricci AD, Gelsomino F, Setola E, Tallini G, de Biase D, Pantaleo MA.
Therapeutic potential of lorlatinib in ALK-mutated metastatic paraganglioma: Insights from clinical case report and literature review
Nigro MC, Corradi G, Nannini M, Di Dalmazi G, Tucci L, Tolento G, Nanni C, Golemi A, De Leo A, De Biase D, Mosconi C, Balacchi C, Vicennati V, Pantaleo MA.
Impact of Human Epidermal Growth Factor Receptor 2 in Patients With Metastatic Colorectal Cancer Treated With Chemotherapy Plus Bevacizumab or Anti-EGFRs: Exploratory Analysis of Eight Randomized Trials
Germani MM, Borelli B, Hashimoto T, Nakamura Y, Oldani S, Battaglin F, Bergamo F, Salvatore L, Stahler A, Antoniotti C, Shitara K, Venook A, Oki E, Muro K, Ugolini C, Soeda J, Lonardi S, Pietrantonio F, Lenz HJ, Modest DP, Yoshino T, Cremolini C.
Risk of disease progression in first-line metastatic colorectal cancer therapy to guide disease reassessments-analysis of 11 trials by AIO and GONO
Germani MM, Heinemann V, Rossini D, Fischer von Weikersthal L, Pietrantonio F, Heinrich K, Stahler A, Lonardi S, Kaiser F, Decker T, Salvatore L, Weiss L, Morano F, Fuchs M, Bergamo F, Antoniotti C, Masi G, Stintzing S, Frumento P, Cremolini C, Modest DP.
Real-world evidences on adjuvant Pembrolizumab for renal cell carcinoma: results from the multicenter real-world ARON-1 study
Kopp RM, Massari F, Grande E, Schieber TJ, Ürün Y, Kopecký J, Molina-Cerrillo J, Basso U, Kucharz J, Büttner T, Pichler R, Fiala O, Myint ZW, Galli L, Buchler T, Rizzo M, Bolek H, Bourlon MT, Conteduca V, Pinto A, Rizzo A, Rosellini M, Roviello G, Zgura A, Mollica V, Partl A, Yildirim A, Akova U, Buti S, Monteiro FSM, Soares A, Porta C, Bilen MA, Li H, Santoni M.
Neoadjuvant immunotherapy for dMMR/MSI-H locally advanced rectal cancer patients: demystifying the 100% clinical complete response paradigm
Marmorino F, Morano F, Canciello MA, Rossi P, Gandini A, Laurent-Puig P, Ugolini C, Martinelli E, Cremolini
C.
Re-treatment with panitumumab followed by regorafenib versus the reverse sequence in chemorefractory metastatic colorectal cancer patients with RAS and BRAF wild-type circulating tumor DNA: the PARERE study by GONO
Ciracì P, Germani MM, Pietrantonio F, Manca P, Lonardi S, Busico A, Bergamo F, Burgio V, Mannavola F, Di Donato S, Fenocchio E, Palermo F, Capone I, De Grandis MC, Pella N, Scartozzi M, Antonuzzo L, Passardi A, Claravezza M, Salvatore L, Tamberi S, Randon G, Conca E, Conca V, Antoniotti C, Moretto R, Masi G, Boni L, Rossini D, Cremolini C; GONO Foundation Investigators.
Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in mice. EBioMedicine.
Farooq Syed, Olivia Ballew, Chih-Chun Lee, Jyoti Rana, Preethi Krishnan, Angela Castela, Staci A Weaver, Namratha Shivani Chalasani, Sofia F Thomaidou, Stephane Demine, Garrick Chang, Alexandra Coomans de Brachène, Maria Ines Alvelos, Lorella Marselli, Kara Orr, Jamie L Felton, Jing Liu, Piero Marchetti, Arnaud Zaldumbide, Donalyn Scheuner, Decio L Eizirik, Carmella Evans-Molina
Inflammation and Prediction of Death in Type 2 Diabetes. Evidence of an Intertwined Link With Tryptophan Metabolism
Claudia Menzaghi, Antonella Marucci, Mario Mastroianno, Giulio Di Ciaccia, Maria Pia Armillotta, Cornelia Prehn, Lucia Salvemini, Davide Mangiacotti, Jerzy Adamski, Andrea Fontana , Salvatore De Cosmo , Olga Lamacchia , Massimiliano Copetti , Vincenzo Trischitta
Correlation analysis between auto-immunological and mutational profiles in myelodysplastic syndromes
Antonio Cristiano, Riccardo Belardi, Hajro Hajrullaj, Emiliano Fabiani, Giulia Falconi, Elisa Galossi, Sergio Bernardini, Maria Teresa Voso, Marzia Nuccetelli
Autotaxin Secretion Is a Stromal Mechanism of Adaptive Resistance to TGFβ Inhibition in Pancreatic Ductal Adenocarcinoma
Silvia Pietrobono, Fabio Sabbadini, Monica Bertolini, Domenico Mangiameli, Veronica De Vita, Federica Fazzini, Giulia Lunardi, Simona Casalino, Enza Scarlato, Valeria Merz, Camilla Zecchetto, Alberto Quinzii, Giusy Di Conza, Michael Lahn, Davide Melis
Key Predictors of Relevant Weight Loss in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease
Nicola Pugliese, Ivan Arcari, Federica Cerini, Rosa Lombardi, Federica Turati, Grazia Pennisi, Matteo Soleri, Simone Rocchetto, Diletta De Deo, Michele Sagasta, Chiara Masetti, Anna Ludovica Fracanzani, Salvatore Petta, Carlo La Vecchia, Mauro Viganò, Alessio Aghemo
HER2-Driven Breast Cancer: Role of the Chaperonin HSP90 in Modulating Response to Trastuzumab-Based Therapeutic Combinations
Italia Falcone, Elena Giontella, Stefano Giuliani, Giulia Borghesani, Alessandro Valenti, Valentina Zambonin, Sara Monteverdi, Luisa Carbognin, Emilio Bria, Ludovica Ciuffreda, Fabiana Conciatori, Chiara Bazzichetto, Serena Pedron, Alessia Nottegar, Sara Zanelli, Alice Muzzarelli, Alessandra Fabi, Silvia Migliaccio, Elisabetta Ferretti, Roberto Bei, Elena Fiorio, Maurizio Fanciulli, Isabella Sperduti, Anna Caliò, Michele Milella
Combination Treatment of Resistant Acute Promyelocytic Leukemia Cells with Arsenic Trioxide and Anti-Apoptotic Gene Inhibitors
Manuela Giansanti, Tiziana Ottone, Serena Travaglini, Maria Teresa Voso, Grazia Graziani, Isabella Faraoni
Not Just CTEPH: A Narrative Review on the Spectrum Approach to Postpulmonary Embolism Conditions
Filippo Biondi, Mattia Alberti, Elisa Montemaggi, Alberto D’Alleva, Rosalinda Madonna
Novel Immune Checkpoint Inhibitor Targets in Advanced or Metastatic Renal Cell Carcinoma: State of the Art and Future Perspectives
Samuele Compagno, Chiara Casadio, Linda Galvani, Matteo Rosellini, Andrea Marchetti, Elisa Tassinari, Pietro Piazza, Angelo Mottaran, Matteo Santoni, Riccardo Schiavina, Francesco Massari, Veronica Mollica
Apoliprotein E-mediated ferroptosis controls cellular proliferation in chronic lymphocytic leukemia
Federica Nardi, Rosita Del Prete, Roberta Drago, Anthea Di Rita, Francesco Edoardo Vallone, Sara Ciofini, Margherita Malchiodi, Laura Pezzella, Laura Tinti, Vittoria Cicaloni, Laura Salvini, Danilo Licastro, Aidan T Pezacki, Christopher J Chang, Giuseppe Marotta, Antonella Naldini, Silvia Deaglio, Tiziana Vaisitti, Alessandro Gozzetti, Monica Bocchia, Anna Kabanova
Sotatercept: A Crosstalk Between Pathways and Activities in the Pulmonary Circulation and Blood
Rosalinda Madonna, Sandra Ghelardoni
Diagnosis and non-invasive assessment of MASLD in type 2 diabetes and obesity
Wah-Kheong Chan, Salvatore Petta, Mazen Noureddin, George Boon Bee Goh, Vincent Wai-Sun Wong
Sotatercept: New drug on the horizon of pulmonary hypertension
Rosalinda Madonna, Filippo Biondi
Predicting the Risk of Adverse Neonatal Outcomes in Women With Insulin-Treated Diabetes: Is It Time for a Pregnancy-Specific Glycemic Risk Index (GRI)?
Fabrizia Citro, Cristina Bianchi, Tommaso Belcari, Federico Galleano, Caterina Venturi, Lorella Battini, Piero Marchetti, Alessandra Bertolotto and Michele Aragona
Preserving momentum on next-generation sequencing for head and neck squamous cell carcinoma
A. Rossi, I. Zampiva, I. Sperduti, F. Conciatori, C. Bazzichetto, R. Nocini, M. Milella
Clinical outcomes of MAFLD versus NAFLD: A meta-analysis of observational studies
Grazia Pennisi, Giuseppe Infantino, Ciro Celsa, Gabriele Di Maria, Marco Enea, Marco Vaccaro, Roberto Cannella, Carlo Ciccioli, Claudia La Mantia, Alessandro Mantovani, Francesco Mercurio, Herbert Tilg, Giovanni Targher, Vito Di Marco, Calogero Cammà, Salvatore Petta
Impact of PNPLA3 I148M on Clinical Outcomes in Patients With MASLD
Salvatore Petta, Angelo Armandi, Elisabetta Bugianesi
Advances in the pathogenesis of FLT3-mutated acute myeloid leukemia and targeted treatments
Travaglini Serena; Gurnari Carmelo ; Ottone Tiziana; Voso Maria Teresa
Risk of liver-related events in metabolic dysfunction–associated steatohepatitis (MASH) patients with fibrosis: A comparative analysis of various risk stratification criteria
Pennisi Grazia; Enea Marco; Romero-Gomez Manuel; Bugianesi Elisabetta; Wai-Sun Wong Vincent; Fracanzani Anna Ludovica; de Ledinghen Victor; George Jacob; Berzigotti Annalisa; Viganò, Mauro; Sebastiani Giada; Cannella Roberto; Delamarre Adèle; Di Maria Gabriele; Lange Naomi F.; Tulone Adele; Di Marco Vito; Cammà Calogero; Petta Salvatore
Predicting early recurrence after resection of initially unresectable colorectal liver metastases: the role of baseline and pre-surgery clinical, radiological and molecular factors in a real-life multicentre experience
R. Moretto, M.M. Germani, B. Borelli, V. Conca, D. Rossini, P. Boraschi, F. Donati, L. Urbani, S. Lonardi, F. Bergamo, K. Cerma, G. Ramondo, F.E. D’Amico, L. Salvatore, G. Valente, B. Barbaro, F. Giuliante, M. Di Maio, G. Masi, C. Cremolini
Glucose metabolism in B cell malignancies: a focus on glycolysis branching pathways
Helga Simon-Molas, Rosita Del Prete, Anna Kabanova
Machine-learning-guided recognition of α and β cells from label-free infrared micrographs of living human islets of Langerhans
Fabio Azzarello, Francesco Carli, Valentina De Lorenzi, Marta Tesi, Piero Marchetti, Fabio Beltram, Francesco Raimondi & Francesco Cardarelli
Role of the Gut–Liver Axis in the Pathobiology of Cholangiopathies: Basic and Clinical Evidence
Maria Consiglia Bragazzi, Rosanna Venere, Anthony Vignone, Domenico Alvaro, Vincenzo Cardinale
Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity
Vanessa Yu, Fiona Yong, Angellica Marta, Sanjay Khadayate, Adrien Osakwe, Supriyo Bhattacharya, Sneha S. Varghese, Pauline Chabosseau, Sayed M. Tabibi, Keran Chen, Eleni Georgiadou, Nazia Parveen, Mara Suleiman, Zoe Stamoulis, Lorella Marselli, Carmela De Luca, Marta Tesi, Giada Ostinelli, Luis Delgadillo-Silva, Xiwei Wu, Yuki Hatanaka, Alex Montoya, James Elliott, Bhavik Patel, Nikita Demchenko, Chad Whilding, Petra Hajkova, Pavel Shliaha, Holger Kramer, Yusuf Ali, Piero Marchetti, Robert Sladek, Sangeeta Dhawan, Dominic J. Withers, Guy A. Rutter & Steven J. Millership
Validation in type 2 diabetes of a metabolomic signature of all-cause mortality
Massimiliano Copetti, Marco Giorgio Baroni, Raffaella Buzzetti, Maria Gisella Cavallo, Efiso Cossu, Paola D’Angelo, Salvatore De Cosmo, Frida Leonetti, Susanna Morano, Lelio Morviducci, Nicola Napoli, Sabrina Prudente, Giuseppe Pugliese, Antonio Fernando Savino, Vincenzo Trischitta
Accuracy of intermittently scanned continuous glucose monitoring during caesarean delivery in pregnant women with insulin-treated diabetes
Fabrizia Citro, Cristina Bianchi, Michele Aragona, Tommaso Belcari, Lorella Battini, Piero Marchetti, Alessandra Bertolotto
Radiomics and deep learning models for CT pre-operative lymph node staging in pancreatic ductal adenocarcinoma: A systematic review and meta-analysis
Roberto Castellana, Salvatore Claudio Fanni, Claudia Roncella, Chiara Romei, Massimiliano Natrella, Emanuele Neri
Non-Invasive Diagnostic Tests for Portal Hypertension in Patients with HBV- and HCV-Related Cirrhosis: A Comprehensive Review
Ciro Celsa, Marzia Veneziano, Francesca Maria Di Giorgio, Simona Cannova, Antonino Lombardo, Emanuele Errigo, Giuseppe Landro, Fabio Simone, Emanuele Sinagra, Vincenza Calvaruso
Molecular and clinical presentation of UBA1-mutated myelodysplastic syndromes
Maria Sirenko, Elsa Bernard, Maria Creignou, Dylan Domenico, Andrea Farina, Juan E. Arango Ossa, Olivier Kosmider, Robert Hasserjian, Martin Jädersten, Ulrich Germing, Guillermo Sanz, Arjan A. van de Loosdrecht, Carmelo Gurnari, Matilde Yung Follo, Felicitas Thol, Lurdes Zamora, Ronald Feitosa Pinheiro, Andrea Pellagatti, Harold K. …
Autophagy, innate immunity, and cardiac disease
Donato Santovito, Sabine Steffens, Serena Barachini, Rosalinda Madonna
ICGC ARGO precision medicine: genomic profiling-informed prediction of immunotherapy response in two patients with metastatic head and neck squamous cell carcinoma
Riccardo Nocini ∙ Luca Tondulli ∙ Consuelo D’Ambrosio ∙ Claudio Luchini ∙ Andrew V Biankin ∙ Raffaella Casolino
Oesophageal varices predict complications in compensated advanced non-alcoholic fatty liver disease
Grazia Pennisi, Marco Enea, Mauro Viganò, Vito Di Marco, Calogero Cammà, Salvatore Petta
Noninvasive assessment of liver disease severity in patients with nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes
Pennisi, Grazia, Enea, Marco, Falco, Vincenzo, Aithal, Guruprasad, Palaniyappan, Naaventhan, Yilmaz, Yusu, Boursier, Jerome, Cassinotto, Christophe, de Lédinghen, Victor, Chan, Wah Kheong, Mahadeva, Sanjiv, Eddowes, Peter, Newsome, Philip, Karlas, Thomas, Wiegand, Johannes, Wong, Vincent Wai-Sun, Schattenberg, Jörn, Labenz, Christian, Kim, Lee, Myoung Seok, Lupsor-Platon, Monica, Cobbold, Jeremy F., Fan, Jian-Gao18, Shen, Feng, Staufer, Katharina, Trauner, Michael, Stauber, Rudolf, Nakajima, Atsushi, Yoneda, Masato, Bugianesi, Elisabetta, Younes, Ramy, Gaia, Silvia, Zheng, Ming-Hua, Cammà, Calogero, Anstee, Quentin, Mózes, Ferenc, Pavlides, Michael, Petta Salvatore