Francesco Candeliere, Enrico Busi, Sara Cerri, Laura Sola, Matteo Lombardi, Stefano Greco, Sara Pedroni, Alberto Amaretti, Stefano Raimondi, Chiara Chiavelli, Maria Giuseppa Vitale, Federica Bertolini, Roberta Depenni, Giorgia Franchini, Massimo Dominici, Maddalena Rossi
Spoke: Spoke 5
Altered abundance in cancer patients gut of diadenylate cyclase-encoding bacteria
Francesco Candeliere, Laura Sola, Enrico Busi, Sara Pedroni, Stefano Raimondi, Alberto Amaretti, Stefano Greco, Massimo Dominici, Maddalena Rossi
Cancer-associated and non-neoplastic fibrosis: Comparative mechanisms and emerging antifibrotic strategies
Beatrice Riccò, Giulia Grisendi, Andrea Lo Monaco, Dilia Giuggioli, Enrico Clini, Massimo Dominici
FDA-Approved Fluorinated Heterocyclic Drugs from 2016 to 2022
Rizzo C, Amata S, Pibiri I, Pace A, Buscemi S, Palumbo Piccionello A
Activation and inhibition of sirtuins: From bench to bedside
Fiorentino F, Fabbrizi E, Mai A, Rotili D
State of the art of carbonic anhydrase activators
Fiorentino F, Carta F, Rotili D, Mai A, Supuran CT.
Red blood cell-derived extracellular vesicles as biomaterials: the opportunity of freezing-induced accelerated aging
Lucia Paolini , Miriam Romano , Valentina Mangolini , Selene Tassoni , Shuhan Jiang , Elena Laura Mazzoldi , Angelo Musicò , Andrea Zendrini, Anna Kashkanova , Vahid Sandoghdar , Anna C Berardi , Silvia Clara Giliani , Paolo Bergese , Annalisa Radeghieri
Improving Machine Learning Classification Predictions through SHAP and Features Analysis Interpretation
L. Bernal, G. Rastelli, L. Pinzi.
Precondensed Plasmid DNA Enhances CAR‑T Cell Generation via Lipid Nanoparticles
Pirrottina, A.; Renzi, S.; Digiacomo, L.; Giulimondi, F.; De Lorenzi, V.; Ghignoli, S.; Pesce, L.; Cardarelli, F.; Mura, F.; Parisi, G.; Buccini, L.; Cassone, C.; Zingoni, A.; Pozzi, D.; Caracciolo, G.
A gene-expression signature defines a subtype of Stomach Adenocarcinomas with low levels of Claudins and a high ratio of NF-YA long/NF-YA short splicing variants
Alberto Gallo, Mirko Ronzio, Maria Barbara Campbell, Sofia Polettini, Enrico Garattini, Roberto Mantovani, Diletta Dolfini.
Fecal microbiota transplantation for decolonization from multidrug-resistant bacteria in pediatric allogeneic hematopoietic stem cell transplantation recipients: a retrospective real-world data study
Masetti R, Barbara G, Muratore E, Marasco G, Cremon C, Marangoni A, Brigidi P, Putignani L, Angelino G, Quagliarella F, Galaverna F, Leardini D, Lazzarotto T, Gabelli M, Savarino E, Zecca M, Faraci M, Prete A, Biffi A, Locatelli F, Merli P.
Hematopoietic stem cell transplantation disrupts age-related gut microbiota signatures in pediatric and adult recipients
Leardini D, Roberto M, Roggiani S, Muratore E, Fabbrini M, Storci G, Tomassini E, Dan E, Schipani A, De Matteis S, Sinigaglia B, Messelodi D, Bertuccio NS, Prete A, Brigidi P, Bonifazi F, Masetti R.
Benefits and concerns of probiotics: an overview of the potential genotoxicity of the colibactin-producing Escherichia coli Nissle 1917 strain
Falzone L, Lavoro A, Candido S, Salmeri M, Zanghì A, Libra M.
Pistachio leaf waste transformed into a gut-targeted bioactive phytocomplex
Spampinato M, Furnari S, Siracusa L, Malfa GA, Distefano A, La Spina E, Gulisano M, Furneri PM, Fuochi V
, Barbagallo IA.
Lactobacilli-Derived Microbe-Associated Molecular Patterns (MAMPs) in Host Immune Modulation
Furnari S, Ciantia R, Garozzo A, Furneri PM, Fuochi V.
Identification of CD320, SLC44A1 and TNFRSF13B as potential novel therapeutic targets for CAR T-cell therapy in multiple myeloma
Francesca Garofano , Anna Maria Corsale , Marta Biondo , Andrea Romano , Ingo Schmidt-Wolf , Anna Maria Gullà , Sergio Siragusa , Cirino Botta
Targeting RNA polymerase I to boost natural killer cell anticancer activity in multiple myeloma
Large scale investigation of GPCR molecular dynamics data uncovers allosteric sites and lateral gateways
CFTR Modulator Response in Nasal Organoids Derived from People with Cystic Fibrosis
Stefania Lo Cicero , Germana Castelli , Aurora Ceci , Anna Maria Cerio , Giovanna Blaconà ,Mariarita Virgulti , Sara Allushi , Giovanni Sette , Francesca Spadaro , Felice Amato , Paola Melotti , Claudio Sorio , Giuseppe Cimino , Mauro Biffoni , Marco Lucarelli and Adriana Eramo
Readthrough Approach Using NV Translational Readthrough-Inducing Drugs (TRIDs): A Study of the Possible Off-Target Effects on Natural Termination Codons (NTCs) on TP53 and Housekeeping Gene Expression
Perriera, R., Vitale, E., Pibiri, I., Carollo, P. S., Ricci, D., Corrao, F., Fiduccia, I., Melfi, R., Zizzo, M. G., Tutone, M., Pace, A., & Lentini, L
.
A precision medicine approach to primary immunodeficiency disease: Ataluren strikes nonsense mutations once again
Lentini, L., Perriera, R., Corrao, F., Melfi, R., Tutone, M., Carollo, P. S., Fiduccia, I., Pace, A., Ricci, D., Genovese, F., Colige, A., Delvenne, P., Grimbacher, B., Moutschen, M., & Pibiri,
I.
CFTR rescue in W1282X cystic fibrosis patient-derived intestinal organoids (PDIOs) mediated by translational readthrough-inducing drugs (TRIDs)
Riccardo Perriera, Anabela S Ramalho , Francois Vermeulen , Emanuele Vitale, Ivana Pibiri , Andrea Pace , Laura Lentini
Advancing Therapeutic Strategies for Nonsense-Related Diseases: From Small Molecules to Nucleic Acid-Based Innovations
Ricci, D., Cruciata, I., Fiduccia, I., Vitale, E., Corrao, F., Branchini, A., Carollo, P. S., Pibiri,
I., & Lentini, L.
Beyond the stop: Oxadiazole TRIDs restore LRBA protein expression in nonsense-driven primary immunodeficiency
Ignazio Fiduccia , Emanuele Vitale , Riccardo Varrica , Davide Ricci , Sefora Marino , Antonino Zito , Andrea Pace , Alain Colige , Michel Moutschen , Yasmin Borutzki , Andrea Bileck , Samuel M Meier-Menches , Laura Lentini ,∗, Ivana Pibiri ,∗∗
Surface antibody changes protein corona both in human and mouse serum but not final opsonization and elimination of targeted polymeric nanoparticles
Sara Capolla , Federico Colombo, Luca De Maso , Prisca Mauro , Paolo Bertoncin , Thilo Kähne , Alexander Engler , Luis Núñez, Ruben Spretz, Gustavo Larsen, Michele Dal Bo, Giuseppe Toffoli, Paolo Macor
Lung function trajectories in common variable immunodeficiencies: An observational retrospective multicenter study
Helena Buso, Davide Firinu, Renato Finco Gambier, Riccardo Scarpa, Giulia Garzi, Valentina Soccodato, Giulia Costanzo, Andrea G. Ledda, Nicolò Rashidy, Ilaria Bertozzi, Stefania Nicola, Giulio Tessarin, Mauro Ramigni, Cinzia Piovesan, Fabrizio Vianello, Andrea Vianello, Stefano Del Giacco, Vassilios Lougaris, Luisa Brussino, Mark G. Jones, Isabella Quinti, Carlo Agostini, Marcello Rattazzi, Cinzia Milito, Francesco Cinetto
Protocol for isolating and culturing neonatal murine cardiomyocytes
Chiara Bongiovanni, Carmen Miano, Francesca Sacchi, Silvia Da Pra, Irene Del Bono, Stefano Boriati, Gabriele D’Uva
Changes in health-related quality of life in common variable immunodeficiency: an eight-year journey, including the COVID-19 pandemic
Federica Pulvirentia,Annalisa Villa, Matteo D’Ambrosi, Gabriella Cusa, Patricia Quijada-Morales, Eduardo de la Fuente-Munoz, Maddalena Sciannamea, Giulia Garzi & Isabella Quinti
The senescence journey in cancer immunoediting
Alessandra Zingoni, Fabrizio Antonangeli, Silvano Sozzani, Angela Santoni, Marco Cippitelli & Alessandra Soriani
Estrogen-related differences in antitumor immunity and the gut microbiome contribute to sexual dimorphism of colorectal cancer
Georgia Lattanzi, Federica Perillo, Angélica Díaz-Basabe, Bruna Caridi, Chiara Amoroso, Alberto Baeri, Elisa Cirrincione, Michele Ghidini, Barbara Galassi, Elisa Cassinotti, Ludovica Baldari, Luigi Boni, Maurizio Vecchi, Flavio Caprioli, Federica Facciotti, Francesco Strati
Targeted therapy for multiple myeloma: an overview on CD138-based strategies
Federico Riccardi, Carmela Tangredi, Michele Dal Bo, Giuseppe Toffoli
From Conventional to Sustainable Catalytic Approaches for Heterocycles Synthesis
Dr. Carla Rizzo, Prof. Andrea Pace, Prof. Ivana Pibiri, Prof. Silvestre Buscemi, Prof. Antonio Palumbo Piccionello
Structure-based mechanism of riboregulation of the metabolic enzyme SHMT1
Sharon Spizzichino, Federica Di Fonzo, Chiara Marabelli, Angela Tramonti, Antonio Chaves-Sanjuan, Alessia Parroni, Giovanna Boumis, Francesca Romana Liberati, Alessio Paone, Linda Celeste Montemiglio, Matteo Ardini, Arjen J. Jakobi, Alok Bharadwaj, Paolo Swuec, Gian Gaetano Tartaglia, Alessandro Paiardini, Roberto Contestabile, Antonello Mai, Dante Rotili, Francesco Fiorentino, Francesca Cutruzzolà
Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity
Martin Pannek, Zayan Alhalabi, Daniela Tomaselli, Martina Menna, Francesco Fiorentino, Dina Robaa, Michael Weyand, Maximilian Puhlmann, Stefano Tomassi, Federica Barreca, Marco Tafani, Elma Zaganjor, Marcia C. Haigis, Wolfgang Sippl, Dante Rotili, Antonello Mai, Clemens Steegborn
Oropharyngeal microbial ecosystem perturbations influence the risk for acute respiratory infections in common variable immunodeficiency
Federica Pulvirenti, Maria Giufrè, Tancredi M. Pentimalli, Romina Camilli, Cinzia Milito, Annalisa Villa, Eleonora Sculco, Marina Cerquetti, Annalisa Pantosti, Isabella Quinti
Optimizing Transfection Efficiency in CAR-T Cell Manufacturing through Multiple Administrations of Lipid-Based Nanoparticles
Francesca Giulimondi, Luca Digiacomo, Serena Renzi, Chiara Cassone, Andrea Pirrottina, Rosa Molfetta, Ilaria Elena Palamà, Gabriele Maiorano, Giuseppe Gigli, Heinz Amenitsch, Daniela Pozzi, Alessandra Zingoni, Giulio Caracciolo
Oleuropein, a Component of Extra Virgin Olive Oil, Improves Liver Steatosis and Lobular Inflammation by Lipopolysaccharides–TLR4 Axis Downregulation
Leonardo Schirone, Diletta Overi, Guido Carpino, Roberto Carnevale, Elena De Falco, Cristina Nocella, Alessandra D’Amico, Simona Bartimoccia, Vittoria Cammisotto, Valentina Castellani, Giacomo Frati, Sebastiano Sciarretta, Eugenio Gaudio, Pasquale Pignatelli, Domenico Alvaro, Francesco Violi
Multiplexed imaging to reveal tissue dendritic cell spatial localisation and function
Giuseppe Rocca, Marco Galli, Anna Celant, Giulia Stucchi, Laura Marongiu, Stefano Cozzi, Metello Innocenti, Francesca Granucci
Genomic and functional analysis of the mucinolytic species Clostridium celatum, Clostridium tertium, and Paraclostridium bifermentans
Francesco Candeliere, Eliana Musmeci, Laura Sola, Alberto Amaretti, Stefano Raimondi, Maddalena Rossi
BMP7 promotes cardiomyocyte regeneration in zebrafish and adult mice
Chiara Bongiovanni, Hanna Bueno-Levy, Denise Posadas Pena, Gilbert Weidinger, Eldad Tzahor, Gabriele D’Uva …
BMP7 promotes cardiomyocyte regeneration
Chiara Bongiovanni, Hanna Bueno-Levy, Denise Posadas Pena, Irene Del Bono, Simone Redaelli, Max Bergen, Silvia Da Pra, Francesca Sacchi, Carmen Miano, Stefano Boriati, Francesca Pontis, Donatella Romaniello, Martina Mazzeschi, Ilaria Petraroia, Riccardo Tassinari, Laura Kellerer, Mattia Lauriola, Carlo Ventura, Stephan Heermann, Gilbert Weidinger, Eldad Tzahor, Gabriele D’Uva
Combining Translation Readthrough Inducing Drugs and Nonsense Mediated Decay Pathway Inhibition to Rescue of CFTRW1282X in Cystic Fibrosis Cell Model System
Roberta Bongiorno, Emanuele Vitale, Davide Ricci, Pietro Salvatore Carollo, Ivana Pibiri, Raffaella Melfi, Andrea Pace, Laura Lentini
BMP signaling promotes heart regeneration via alleviation of replication stress
Mohan Dalvoy Vasudevarao, Denise Posadas Pena, Michaela Ihle, Chiara Bongiovanni, Pallab Maity, Simone Redaelli, Kathrin Happ, Dominik Geissler, Hossein Falah Mohammadi, Melanie Rall-Scharpf, Chi-Chung Wu, Arica Beisaw, Karin Scharffetter-Kochanek, Gabriele D’Uva, Lisa Wiesmüller, Gilbert Weidinger
Insights into the Structural Conformations of the Tau Protein in Different Aggregation Status
Luca Pinzi, Nicolò Bisi, Claudia Sorbi, Silvia Franchini, Nicolò Tonali and Giulio Rastelli
Lactobacillus rhamnosus GG cell-free supernatant as a novel anti-cancer adjuvant
Rossella Salemi, Silvia Vivarelli, Daria Ricci, Marina Scillato, Maria Santagati, Giuseppe Gattuso, Luca Falzone & Massimo Libra
Anti-tumor activity of all-trans retinoic acid in gastric-cancer: gene-networks and molecular mechanisms
Luca Guarrera, Mami Kurosaki, Silvio-Ken Garattini, Maurizio Giannì, Gianpiero Fasola, Luca Rossit, Michele Prisciandaro, Maria Di Bartolomeo, Marco Bolis, Paola Rizzo, Claudia Nastasi, Marika Foglia, Adriana Zanetti, Gabriela Paroni, Mineko Terao, Enrico Garattini
Chemotherapy-induced neutropenia elicits metastasis formation in mice by promoting proliferation of disseminated tumor cells
Massimo Russo, Nicolò Panini, Paola Fabbrizio, Laura Formenti, Riccardo Becchetti, Cristina Matteo, Marina Meroni, Claudia Nastasi, Andrea Cappelleri, Roberta Frapolli, Giovanni Nardo, Eugenio Scanziani, Andrea Ponzetta, Maria Rosa Bani, Carmen Ghilardi, Raffaella Giavazzi
In silico analysis and theratyping of an ultra-rare CFTR genotype (W57G/A234D) in primary human rectal and nasal epithelial cells
Karina Kleinfelder, Virginia Lotti, Adriana Eramo, Marco Lucarelli, Paola Melotti, Claudio Sorio…
Trends and Applications in Computationally Driven Drug Repurposing
Luca Pinzi and Giulio Rastelli
A novel complement-fixing IgM antibody targeting GPC1 as a useful immunotherapeutic strategy for the treatment of pancreatic ductal adenocarcinoma
Davide Busato, Sara Capolla, Paolo Durigutto, Monica Mossenta, Sara Bozzer, Daniele Sblattero, Paolo Macor, Michele Dal Bo & Giuseppe Toffoli