Claire D James, Aya H Youssef, Jenny D Roe, Floriana Cappiello, Francesca Antonella Aiello, Benedetta Perdichizzi, Rachel L Lewis, Austin Witt, Apurva T Prabhakar, Xu Wang, Molly L Bristol, Pietro Pichierri, Iain M Morgan
Spoke: Spoke 3
Multi-Class Segmentation and Classification of Intestinal Organoids: YOLO Stand-Alone vs. Hybrid Machine Learning Pipelines
Conte L, De Nunzio G, Raso G, Cascio D.
The WWP1-JARID1B axis sustains acute myeloid leukemia chemoresistance
Claudia Fierro , Sara Giovannini , Valeria Moriconi , Claudia Fiorilli , Emanuele Panatta , Valentina Frezza , Federica Corigliano , Rosalba Pecorari , Yanan Li , Ji Zhou , Vincenza Simona Delvecchio , Artem Smirnov , Jose Manuel Garcia Manteiga , Andrea Brendolan , Jinping Zhang , Yufang Shi , Ivano Amelio , Eleonora Candi , Gerry Melino, Francesca Bernassola
The role of HECT-type E3 ubiquitin ligases in DNA damage response and repair
Giovannini S, Fiorilli C, Moriconi V, Shi Y, Candi E, Melino G, Bernassola F.
Decoding the role of mesothelin in tumor dynamics and targeted treatment innovations
Silvestri R, Colucci E, Piccardi M, Landi S, Gemignani F
Development of a Mesothelin-Binding Engineered Scaffold Protein as a Theranostic for Pleural Mesothelioma
Silvestri R, Piccardi M, Laurenza A, Rea F, Sirois AR, Lari M, Bartoli F, Signore G, Tedeschi L, Ferraro E, Erba PA, Giovannoni R, Landi S, Gemignani F, Moore SJ.
Synthesis and Application of a Glucoconjugated Organometallic Rhenium Complex as an IR Imaging Probe for Glycolytic Cancer Cells
Bononi G, Paltrinieri E, Fortunato S, Cicio G, Di Giovanni N, Lencioni G, Funel N, Giovannetti E, Granchi C, Di Bussolo V,
Minutolo F.
Gene expression in organoids: an expanding horizon
Artem Smirnov , Gerry Melino , Eleonora Candi
Transcriptomic Profile of Human Osteoblast-like Cells Grown on Trabecular Titanium
Giovanna Castoldi , Mario Mauri , Deborah D’Aliberti , Silvia Spinelli , Leonardo Testa , Federico Gaverina , Alessandro Rubinacci , Isabella Villa , Giuseppe Bellelli , Gianpaolo Zerbini , Rocco Piazza , Giovanni Zatti
Deletion of p63 exon 13 in mice reveals C-terminal isoform-specific functions in epithelial development
Nannini M, Astolfi A, Maloberti T, Nigro MC, Gozzellino L, Costa A, Pirini MG, De Leo A, Grillini M, Altimari A, Del Gaudio M, Vincenzi B, Fumagalli E, Brunello A, Grignani G, Aliberti S, Ricci AD, Gelsomino F, Setola E, Tallini G, de Biase D, Pantaleo MA.
Impairment of oxidative metabolism compromises Rad51 recruitment and potentiates PARP inhibitor effectiveness in ovarian cancer
Laura Formenti, Francesca Abramo, Giulia Dellavedova, Valentina Dematteis, Alessandra Decio, Chiara Grasselli, Paola Fabbrizio, Laura Brunelli, Raffaella Giavazzi, Carmen Ghilardi
Rationalizing the structural basis of organic-platinum hybrid complexes binding towards quadruplex-duplex hybrids through all-atom simulations
Salvatore Muscarella, Irene Treccarichi, Luisa D’Anna, Angelo Spinello
Astrocytes differentiated from patient iPSCs model the rare leukodystrophy MLC and uncover disease-linked maturation defects and Kir4.1 channel dysfunction
Angela Lanciotti, Maria Stefania Brignone, Chiara De Nuccio, Sara Sposito, Elena Sofia Caprini, Marcello Belfiore, Francesco Nicita, Caterina Veroni, Chiara Meloni, Rosalba Carrozzo, Teresa Rizza, Chiara Aiello, Jacopo Sartorelli, Enrico Bertini, Sergio Visentin, Elena Ambrosini
Glial Ion Channels in Myelin Pathophysiology: Insights from Leukodystrophies
Belfiore M, Visentin S, Ambrosini E.
PGC-1α: key regulator of mitochondrial biogenesis and cellular differentiation in metabolic and regenerative tissues
Lijuan Cao, Yanan Li, Artem Smirnov, Ramouna Voshtani, Tingting Wang, Changshun Shao, Eleonora Candi, Gerry Melino, Yufang Shi, Jiankai Fang
Decoding cancer dormancy: integrative genomic, phenotypic and live-cell imaging analysis to reveal the hidden cancer cell reservoir
Gaetana Porcelli, Caterina D’Accardo, Francesca Angeloro, Martina Cucchiara, Paola Bianca, Vincenzo Davide Pantina, Narges Roozafzay, Chiara Modica, Miriam Gaggianesi, Sebastiano Di Bella, Giorgio Stassi, Alice Turdo, Matilde Todaro
Adipocyte/Tumor cell crosstalk via IGF-1/TXNIP axis promotes malignancy and endocrine resistance in breast cancer
Amanda Caruso, Felice Maria Accattatis, Cinzia Giordano, Luca Gelsomino, Piercarlo Del Console, Maria Francesca Fiorita, Balazs Gyorffy, Laura Bianchi, Alfonso Carleo, Rossana De Salvo, Bruno M Simões, Robert B Clarke, Lorenzo Memeo, Cristina Colarossi, Eleonora Aiello, Francesco Conforti, Suzanne A W Fuqua, Matilde Todaro, Giorgio Stassi, Catia Morelli, Diego Sisci, Daniela Bonofiglio, Stefania Catalano, Sebastiano Andò, Ines Barone
Protocol to investigate cell cycle-dependent modes of micronucleus formation using dual-pulse nascent DNA labeling
Pepe S, Duardo RC, Capranico G, Marinello J.
Mesenchymal stromal cells highly expressing Sca-1 promote breast cancer lung metastasis through recruiting myeloid cells
Lijuan Cao, Yanan Li, Minghui Ou, Artem Smirnov, Rui Liu, Tingting Wang, Xiao Su, Peishan Li, Mancini Mara, Eleonora Candi, Zhiyuan Zheng, Gerry Melino, Changshun Shao, Yufang Shi
Rheology and Printability of Hydroxyapatite/Sodium Alginate Bioinks Added with Bovine or Fish Collagen Peptides
Milazzo M, Rovelli R, Ricci C, Macchi T, Gallone G, Danti S.
Rheological Characterization of Marine and Bovine Collagen Peptides/Acetic Acid Slurries Incorporating Hydroxyapatite Nanoparticles
Mario Milazzo, Claudio Ricci, Eugenio Redolfi Riva, Damiano Rossi, Irene Anguillesi, Maurizia Seggiani, Giuseppe Gallone, Serena Danti
The role of 3D preclinical models in the Era of precision medicine: A bladder cancer perspective
Carlotta Frascolla, Riccardo Mastroianni, Giuseppe Simone, Giovanni Blandino
Dissecting endometrial cancer complexity in response to standard and targeted therapies
Sebastiano Vaccarella, Valentina Bruno, Giulia Orlandi, Daniela Angela Covino, Carlotta Frascolla, Claudio Pulito, Riccardo Vizza, Giulia Urbani, Matteo Allegretti, Valentina De Pascale, Frauke Goeman, Ludovica Ciuffreda, Brindusa Ana Maria Arteni, Simona Di Martino, Andrea Sacconi, Emanuela Mancini, Anna Bagnato, Ermelinda Baiocco, Ramy Kajal, Yaron Vinik, Sima Lev, Maurizio Fanciulli, Antonello Vidiri, Mariantonia Carosi, Sabrina Strano, Sara Donzelli, Enrico Vizza, Giovanni Blandino
A New Algal Friendly Extract from Euglena cantabrica with Potential Applications in Biomedical Field
Buonvino S, Trinca C, Leu S, Licoccia S, Melino S.
Effect of pesticides on breast cancer tum
Marcoccia D, Palomba S, Brajon G, Baldi A, Galli FS, Servadei F, Palumbo V, Bonfiglio R, Treglia M, Marsella LT, Botti F, Shi Y, Candi E, Melino G, Mauriello A, Scimeca M.
Evidence of fructose metabolism in colorectal cancer
Sica GS, Bischof J, Funke L, Hartmut J, Candi E, Mauriello A, Scimeca M, Gao X, Savino L, Servadei F, Yang R, Wang L, Zhao Q, Chen WL, Sun Q, Jia W, Melino G.
Prevention of hydrocephalus with a small oligonucleotide. Mol Ther.
Lilit Antonyan, Linda Bossini, Xin Zhang, Anjie Ni, Marc-Daniel Hagel, Eva Baronchelli, Martina Geusa, Huashan Peng, Amelia Semenak, Peter Fleming, Shaima Alsuwaidi, Ying Zhang, Beili Hu, Diletta Fontana, Valentina Crippa, Stefania Codazzi, Julia Macintosh, Andres Arriaga-Sierra, Basil Khan, Nuwan Hettige, Malvin Jefri, Yijing Liang, Stephanie Klein, André du Toit, Nhu T N Phan, Andreas Schuppert, Yang Zhou, Rocco Piazza, Keith Murai, Sebastien Jacquemont, Alessandro Sessa, Carl Ernst
Fetal-restricted hematopoietic progenitors arise from hemogenic endothelium in vitelline and umbilical arteries.
Cristiana Barone, Giulia Quattrini, Alessandro Muratore, Giorgio Anselmi, Yurim Park, Naeema T Mehmood, Elena Morganti, Roberto Orsenigo, Filipa Timóteo-Ferreira, Anna Cazzola, Arianna Patelli, Thea Milanesi, Bianca Nesti, Francisca Soares-da-Silva, Matthew Nicholls, Gloria Zambelli, Mario Mauri, Silvia Bombelli, Sofia De Marco, Deborah D’Aliberti, Silvia Spinelli, Veronica Bonalume, Alison Domingues, Mahdieh Naghavi Alhosseini , Gianluca Sala, Arianna Colonna, Elisabetta D’Errico, Cristina D’Orlando, Cristina Bianchi, Roberto A Perego, Raffaella Meneveri, Ana Cumano, Silvia Brunelli, Marella F T R De Bruijn, Andrea Ditadi, Alessandro Fantin, Rocco Piazza, Emanuele Azzoni
Metabolic Signature of FLT3-Mutated AML: Clinical and Therapeutic Implications.
Banella C, Catalano G, Calvani M, Candi E, Noguera NI, Travaglini S.
The WWP1–JARID1B axis sustains acute myeloid leukemia chemoresistance.
Claudia Fierro, Sara Giovannini, Valeria Moriconi, Claudia Fiorilli, Emanuele Panatta, Valentina Frezza, Federica Corigliano, Rosalba Pecorari, Yanan Li Ji Zhou, Vincenza Simona Delvecchio, Artem Smirnov, Jose Manuel Garcia Manteiga, Andrea Brendolan, Jinping Zhang, Yufang Shi, Ivano Amelio, Eleonora Candi, Gerry Melino, Francesca Bernassola
The role of HECT-type E3 ubiquitin ligases in DNA damage response and repair. Cell Death Discov.
Giovannini S, Fiorilli C, Moriconi V, Shi Y, Candi E, Melino G, Bernassola F.
Multi-omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine
Livia Concetti 1, Manuel Scimeca 1, Julia Bischof 2, Jonathan Woodsmith 2, Massimiliano Agostini 1, Cristina Fiorani 3, Yufang Shi 4, Eleonora Candi 1, Gerry Melino 1, Alessandro Mauriello 1, Giuseppe S Sica
ANP32E drives vulnerability to ATR inhibitors by inducing R-loops-dependent Transcription Replication Conflicts in Triple Negative Breast Cancer
Sara Lago, Vittoria Poli, Lisa Fol, Mattia Botteon, Alessandra Fasciani, Alice Turdo, Miriam Gaggianesi, Matilde Todaro, Yari Ciani, Giacomo D’Amato, Francesca Demichelis, Alessio Zippo
Human Umbilical Cord-Mesenchymal Stem Cells Promote Extracellular Matrix Remodeling in Microglia
Marta Tiffany Lombardo, Martina Gabrielli, Florence Julien-Marsollier, Valérie Faivre, Tifenn Le Charpentier 3 Z, Cindy Bokobza, Deborah D’Aliberti, Nicola Pelizzi, Camilla Halimi, Silvia Spinelli, Juliette Van Steenwinckel, Elisabetta A. M. Verderio, D. Pierre Gressens, Rocco Piazza and Claudia Verderio
Elisabetta A. M. Verderio, Pierre Gressens, Rocco Piazza and Claudia Verderio
Next Generation Sequencing Identifies Subgroups of Patients With Triple Negative Primary Thrombocytosis With Different Clinical Thrombotic Outcomes
Valentina Sangiorgio, Federica Mottadelli, Fabio Pagni, Fabrizio Cavalca, Giovanni Cazzaniga, Martina Venegoni, Carlo Gambacorti-Passerini, Rocco Piazza, Elena Maria Elli
Stroma gene signature predicts responsiveness to chemotherapy in pancreatic ductal adenocarcinoma patient-derived xenograft models
Alessia Anastasia, Laura Formenti, Paola Ostano, Lucia Minoli, Andrea Resovi, Lavinia Morosi, Claudia Fioravanti, Edoardo Micotti, Cristina Matteo, Eugenio Scanziani, Giovanna Chiorino, Raffaella Giavazzi, Carmen Ghilardi, Dorina Belotti
Mathematical modeling of the synergistic interplay of radiotherapy and immunotherapy in anti-cancer treatments
Paolo Castorina, FIlippo Castiglione, Gianluca Ferini, Stefano Forte, Emanuele Martorana, Dario Giuffrida
Stimulation of cGAS-STING pathway as a challenge in the treatment of small cell lung cancer: a feasible strategy?
Giulia Miglietta, Marco Russo, Giovanni Capranico & Jessica Marinello
CircPVT1 weakens miR-33a-5p unleashing the c-MYC/GLS1 metabolic axis in breast cancer
Alina Catalina Palcau, Claudio Pulito, Valentina De Pascale, Luca Casadei, Mariacristina Valerio, Andrea Sacconi, Valeria Canu, Daniela Rutigliano, Sara Donzelli, Federica Lo Sardo, Francesca Romana Auciello, Fulvia Pimpinelli, Paola Muti, Claudio Botti, Sabrina Strano, Giovanni Blandino
Cancer stem cells and tumor-associated macrophages as mates in tumor progression: mechanisms of crosstalk and advanced bioinformatic tools to dissect their phenotypes and interaction
Francesco Verona , Sebastiano Di Bella, Roberto Schirano, Camilla Manfredi, Francesca Angeloro, Giulia Bozzari, Matilde Todaro, Giuseppe Giannini, Giorgio Stassi, Veronica Veschi
Deep Learning Approaches for Morphological Classification of Intestinal Organoids
Giovanni Cicceri, Sebastiano Di Bella, Simone Di Franco, Giorgio Stassi, Matilde Todaro, Salvatore Vitabile
Genomic context influences translesion synthesis DNA polymerase-dependent mechanisms of micronuclei induction by G-quadruplexes
Simona Pepe, Federico Guerra, Marco Russo, Renée, Duardo, Giovanni Capranico
DDGemb: predicting protein stability change upon single- and multi-point variations with embeddings and deep learning
Castrense Savojardo , Matteo Manfredi , Pier Luigi Martelli , Rita Casadio
An Optimized NGS Workflow Defines Genetically Based Prognostic Categories for Patients with Uveal Melanoma
Michele Massimino, Elena Tirrò,Stefania Stella, Cristina Tomarchio, Sebastiano Di Bella,Silvia Rita Vitale, Chiara Conti, Marialuisa Puglisi, Rosa Maria Di Crescenzo, Silvia Varricchio, Francesco Merolla, Giuseppe Broggi, Federica Martorana, Alice Turdo, Miriam Gaggianesi, Livia Manzella, Andrea Russo, Giorgio Stassi, Rosario Caltabiano, Stefania Staibano
Anaplastic Lymphoma Kinase (ALK) Inhibitors Enhance Phagocytosis Induced by CD47 Blockade in Sensitive and Resistant ALK-Driven Malignancies
Federica Malighetti, Matteo Villa, Mario Mauri, Simone Piane,Valentina Crippa, Ilaria Crespiatico, Federica Cocito,Elisa Bossi, Carolina Steidl, Ivan Civettini ,Chiara Scollo ,Daniele Ramazzotti, Carlo Gambacorti-Passerini, Rocco Piazza,Luca Mologni, Andrea Aroldi
Biallelic PI4KA Mutations Disrupt B-Cell Metabolism and Cause B-Cell Lymphopenia and Hypogammaglobulinemia
Francesco Saettini, Fabiola Guerra, Mario Mauri, Claire G. Salter, Margaret P. Adam, David Adams, Emma L. Baple, Estibaliz Barredo, Sanil Bhatia, Arndt Borkhardt, Alfredo Brusco, Cristina Bugarin, Clizia Chinello, Andrew H. Crosby, Precilla D’Souza, Vanna Denti, Grazia Fazio, Silvia Giuliani, Hye Sun Kuehn, Hassan Amel, Asha Elmi, Bernice Lo, Federica Malighetti, Giorgia Mandrile, Andrea Biondi
BRCA1 foci test as a predictive biomarker of olaparib response in ovarian cancer patient-derived xenograft models
Federica Guffanti, Ilaria Mengoli, Maria Francesca Alvisi, Giulia Dellavedova, Raffaella Giavazzi, Robert Fruscio, Eliana Rulli, Giovanna Damia
ARID1A Mutations in Gastric Cancer: A Review with Focus on Clinicopathological Features, Molecular Background and Diagnostic Interpretation
Giuseppe Angelico, Giulio Attanasio, Lorenzo Colarossi, Cristina Colarossi, Matteo Montalbano, Eleonora Aiello, Federica Di Vendra, Marzia Mare, Nicolas Orsi, Lorenzo Memeo
New Parametric 2D Curves for Modeling Prostate Shape in Magnetic Resonance Images
Rosario Corso, Albert Comelli, Giuseppe Salvaggio, Domenico Tegolo
First-hit SETBP1 mutations cause a myeloproliferative disorder with bone marrow fibrosis
Ilaria Crespiatico, Mattia Zaghi, Cristina Mastini, Deborah D’Aliberti, Mario Mauri, Carl Mirko Mercado, Diletta Fontana, Silvia Spinelli, Valentina Crippa, Elena Inzoli, Beatrice Manghisi, Ivan Civettini, Daniele Ramazzotti, Valentina Sangiorgio, Michele Gengotti, Virginia Brambilla, Andrea Aroldi, Federica Banfi, Cristiana Barone, Roberto Orsenigo, Ludovica Riera, Mara Riminucci, Alessandro Corsi, Massimo Breccia, Alessandro Morotti, Daniela Cilloni, Aldo Roccaro, Antonio Sacco, Fabio Stagno, Marta Serafini, Federica Mottadelli, Giovanni Cazzaniga, Fabio Pagni, Roberto Chiarle, Emanuele Azzoni, Alessandro Sessa, Carlo Gambacorti-Passerini, Elena Maria Elli, Luca Mologni, Rocco Piazza