The Second International Conference on Prescriptomics and Precision Medicine, a reference scientific event for experts and pioneers in the sector at a global level, took place from 25 to 28 May 2025 in Caparica – Lisbon (Portugal). The conference is organized by Prof. J.L. Capelo Martinez, C. Lodeiro and H.M. Santos of the Nova Universidade of Lisbon, leading experts in the field of Precision Medicine of Omic Technologies. This year’s edition saw a significantly expanded participation by the HEAL Italia Partnership, which actively contributed to the congress proceedings with high-profile reports.
In particular, two keynote lectures were entrusted to representatives of the Partnership.
Professor Ivana Pibiri of the University of Palermo held a lecture entitled “A Journey Beyond Nonsense: Precision Therapy as Path to Cure nonsense derived Duchenne Muscular Dystrophy (nd-DMD)”;
Professor Federica Pellati of the University of Modena and Reggio Emilia presented a lecture on the topic “Cannabis-based medicines and cannabinoids in the personalized therapy of pain”, receiving an award from the scientific society ProteoMass for innovation in the field of pharmaceutical chemistry and precision medicine.
To enrich the conference, the thematic session dedicated to Rare Diseases, coordinated by Prof. Pibiri, hosted five invited oral presentations, two of which were from our partners:
Prof. Gianluca Moroncini, Director of the HEAL ITALIA Precision Medicine Center for Rare Diseases in Ancona, presented “Gene Expression Profiling of Primary Raynaud’s Phenomenon and Very Early Systemic Sclerosis Patients Reveals Novel Biomarkers of Fibrosis Onset and Progression”;
Prof. Emanuela Craparo of the University of Palermo presented “Nanomedicine in Precision Approaches to Cystic Fibrosis Therapy”.
On the topic of rare diseases, there was also a shotgun presentation by Dr. Davide Ricci, who won the best shot-gun poster communication award with “New Therapeutic Approach In Cystic Fibrosis Under The Lens: Evaluating The Proteomic Impact Of Translational Readthorugh Based Therapy In Mice Model”.
Prof. Marco Tutone spoke in the session “Advancing Diagnostics/Therapy with Genomics & Proteomics” with a presentation entitled “Design of small molecules and identification of putative anticancer therapeutic targets via in silico tools”, and Dr. Giulia Culletta won an award for the best shot-gun poster communication “A comprehensive computational analysis of NR2F2/6 receptors for drug repurposing”.
Finally, the PhD student from Modena Dr. Laura Bertarini, who is part of the HEAL Italia project, won an award for best poster communication entitled “Lipidomic profiling of MASLD: identifying lipid biomarkers for detection and stratification of disease severity”.
The conference was an important event for the in-depth analysis of the most recent innovations in the field of precision medicine, with a focus on the advances in omics sciences and artificial intelligence. Central themes were the complex interaction between genetics, transcriptomics, proteomics, metabolomics and epigenetics, and their impact on the efficacy and safety of personalized therapies.
After the success of the first edition, this second event reaffirmed the growing importance of prescriptomics in the medicine of the future. The works ranged from strategies for the collection and management of biological samples, to the use of omics technologies in the diagnostic field, to patient follow-up, to bioinformatics and the integration of artificial intelligence to improve prescription precision, up to the use of point-of-care devices.
The approach that emerged aims to overcome traditional therapeutic models, promoting increasingly personalized medicine, capable of reducing adverse effects and optimizing clinical outcomes, in a transformative perspective that marks a clear change in contemporary healthcare practice.
Once again, the conference offered a scientifically very stimulating environment, ideal for the birth of new collaborations, joint projects and shared visions, which will guide the next evolutions in this revolutionary field of biomedical research.