The Second International Conference on Prescriptomics and Precision Medicine, a leading scientific event for global experts and pioneers in the field, took place from May 25 to 28, 2025, in Caparica, Lisbon, Portugal. The conference is organized by Professors J.L. Capelo Martinez, C. Lodeiro, and H.M. Santos of Nova Universidade de Lisbon, leading experts in the field of Precision Medicine and Omic Technologies. This year’s edition saw significantly expanded participation from the HEAL Italia Partnership, which actively contributed to the conference proceedings with high-profile presentations.
Specifically, two keynote lectures were given by representatives of the Partnership.
Professor Ivana Pibiri of the University of Palermo gave a lecture entitled “A Journey Beyond Nonsense: Precision Therapy as a Path to Cure Nonsense-derived Duchenne Muscular Dystrophy (nd-DMD)”; Professor Federica Pellati of the University of Modena and Reggio Emilia presented a lecture on “Cannabis-based Medicines and Cannabinoids in the Personalized Therapy of Pain,” receiving an award from the scientific society ProteoMass for innovation in pharmaceutical chemistry and precision medicine.
Enriching the conference, the thematic session dedicated to Rare Diseases, coordinated by Professor Pibiri, featured five invited oral presentations, two of which were from our partners: Professor Gianluca Moroncini, Director of the HEAL ITALIA Precision Medicine Center for Rare Diseases in Ancona, presented “Gene Expression Profiling of Primary Raynaud’s Phenomenon and Very Early Systemic Sclerosis Patients Reveals Novel Biomarkers of Fibrosis Onset and Progression”; Professor Emanuela Craparo of the University of Palermo presented “Nanomedicine in Precision Approaches to Cystic Fibrosis Therapy.” Also on the topic of rare diseases was a shotgun presentation by Dr. Davide Ricci, who won the award for best shotgun poster communication with “New Therapeutic Approach In Cystic Fibrosis Under The Lens: Evaluating The Proteomic Impact Of Translational Readthrough-Based Therapy In Mice Model.” Professor Marco Tutone spoke in the “Advancing Diagnostics/Therapy with Genomics & Proteomics” session with a presentation entitled “Design of small molecules and identification of putative anticancer therapeutic targets via in silico tools,” and Dr. Giulia Culletta won an award for best shotgun poster communication for her presentation “A comprehensive computational analysis of NR2F2/6 receptors for drug repurposing.”
Finally, Modena PhD student Dr. Laura Bertarini, part of the HEAL Italia project, won an award for best poster communication for her presentation “Lipidomic profiling of MASLD: identifying lipid biomarkers for detection and stratification of disease severity.”
The conference was an important opportunity to explore the latest innovations in precision medicine, with a focus on advances in omics science and artificial intelligence. Central themes were the complex interplay between genetics, transcriptomics, proteomics, metabolomics, and epigenetics, and their impact on the efficacy and safety of personalized therapies. Following the success of the first edition, this second event reaffirmed the growing importance of prescriptomics in future medicine. Discussions ranged from strategies for collecting and managing biological samples, to the use of omics technologies in diagnostics, patient follow-up, bioinformatics, and the integration of artificial intelligence to improve prescription precision, all the way to the use of point-of-care devices.
The emerging approach aims to transcend traditional therapeutic models, promoting increasingly personalized medicine capable of reducing adverse effects and optimizing clinical outcomes. This transformative approach marks a significant shift in contemporary healthcare practice. Once again, the conference offered a highly scientifically stimulating environment, ideal for the emergence of new collaborations, joint projects, and shared visions that will guide future developments in this revolutionary field of biomedical research.