Open Science Publications

SPOKE 1 Publications

DOI Metabolic regulation by p53 prevents R-loop-associated genomic instability
DOI Extracellular serine empowers epidermal proliferation and psoriasis-like symptoms
DOI Transglutaminase type 2-dependent crosslinking of IRF3 in dying melanoma cells
DOI Serine and one-carbon metabolism sustain non-melanoma skin cancer progression
DOI Gene expression in organoids: an expanding horizon
DOI A Novel Prognostic Biomarker in Metastatic Prostate Cancer
DOI Apoptotic cell death in disease—Current understanding of the NCCD 2023
DOI NAADP-Evoked Ca2+ Signaling Leads to Mutant Huntingtin Aggregation and Autophagy Impairment in Murine Astrocytes
DOI The STING/TBK1/IRF3/IFN type I pathway is defective in cystic fibrosis
DOI Type 2 transglutaminase in the nucleus: the new epigenetic face of a cytoplasmic enzyme
DOI Sustainable Vegetable Oil-Based Biomaterials: Synthesis and Biomedical Applications
DOI ZFP750 affects the cutaneous barrier through regulating lipid metabolism
DOI Microbiota-gut-brain axis: relationships among the vagus nerve, gut microbiota, obesity, and diabetes
DOI To metabolomics and beyond: a technological portfolio to investigate cancer metabolism
DOI Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies
DOI Hippo Pathway Activation in Aged Mesenchymal Stem Cells Contributes to the Dysregulation of Hepatic Inflammation in Aged Mice
DOI Harnessing metabolism of hepatic macrophages to aid liver regeneration
DOI The ubiquitin ligase TRIM32 promotes the autophagic response to Mycobacterium tuberculosis infection in macrophages
DOI Programmed Cell Death Pathways in Cholangiocarcinoma: Opportunities for Targeted Therapy
DOI Transglutaminase 2 and Ferroptosis: a new liaison?

SPOKE 2 Publications

DOI Artificial intelligence-based models to assess the risk of malignancy on radiological imaging in patients with intraductal papillary mucinous neoplasm of the pancreas: scoping review
DOI Efficacy of MRI data harmonization in the age of machine learning. A multicenter study across 36 datasets
DOI A detailed mathematical model of the human atrial cardiomyocyte: integration of electrophysiology and cardiomechanics

SPOKE 3 Publications

DOI Recapitulating thyroid cancer histotypes through engineering embryonic stem cells
DOI In Vitro Models of Bacterial Biofilms: Innovative Tools to Improve Understanding and Treatment of Infections
DOI Nanoparticles: Synthesis, Pegylation, Characterization and Study of Their Luminescence Properties
DOI Metadynamics simulations for the investigation of drug loading on functionalized inorganic nanoparticles
DOI Gene expression in organoids: an expanding horizon
DOI Sustainable Vegetable Oil-Based Biomaterials: Synthesis and Biomedical Applications
DOI Serine and one-carbon metabolism sustain non-melanoma skin cancer progression
DOI Ca2+ signaling and cell death

SPOKE 4 Publications

DOI Sex hormones differentially contribute to Parkinson disease in males: A multimodal biomarker study
DOI Assessing the relationship between cardiovascular and small airway disease and acute events in COPD: The ARCADIA study protocol
DOI Value of Artificial Intelligence in Evaluating Lymph Node Metastases
DOI MiR-494 induces metabolic changes through G6pc targeting and modulates sorafenib response in hepatocellular carcinoma
DOI Personalised antiplatelet therapies for coronary artery disease: what the future holds
DOI Altered Thyroid Feedback Loop in Klinefelter Syndrome: From Infancy Through the Transition to Adulthood
DOI Prospective Validation Study of a Novel Integrated Pathway Based on Clinical Features, Magnetic Resonance Imaging Biomarkers, and MicroRNAs for Early Detection of Prostate Cancer
DOI Clinical and neurochemical correlates of the APOE genotype in early-stage Parkinson’s disease
DOI Advancing the PD-L1 CPS test in metastatic TNBC: Insights from pathologists and findings from a nationwide survey
DOI Cost analysis of archives in the pathology laboratories: from safety to management
DOI Management of Coronary Artery Disease in Older Adults: Recent Advances and Gaps in Evidence
DOI Total Bio-Based Material for Drug Delivery and Iron Chelation to Fight Cancer through Antimicrobial Activity
DOI Atrial natriuretic peptide stimulates autophagy/mitophagy and improves mitochondrial function in chronic heart failure
DOI High-risk TP53 mutations predict poor primary treatment response of patients with head and neck squamous cell carcinoma
DOI The Immune Cells in the Development of Oral Squamous Cell Carcinoma

SPOKE 5 Publications

DOI Lactobacillus rhamnosus GG cell-free supernatant as a novel anti-cancer adjuvant
DOI Insights into the Structural Conformations of the Tau Protein in Different Aggregation Status
DOI L1077P CFTR pathogenic variant function rescue by Elexacaftor–Tezacaftor–Ivacaftor in cystic fibrosis patient-derived air–liquid interface (ALI) cultures and organoids: in vitro guided personalized therapy of non-F508del patients
DOI Readthrough approach by NV translational readthrough inducing drugs (TRIDs): a study of the possible off-target effects on natural termination codons (NTCs) on TP53 and housekeeping genes expression.
DOI BMP7 promotes cardiomyocyte regeneration
DOI Decline of gastric cancer mortality in common variable immunodeficiency in the years 2018-2022

SPOKE 6 Publications

DOI Er:Y2O3 and Nd:Y2O3 Nanoparticles: Synthesis, Pegylation, Characterization and Study of Their Luminescence Properties
DOI Metadynamics simulations for the investigation of drug loading on functionalized inorganic nanoparticles
DOI Chasing the Role of miRNAs in RCC: From Free-Circulating to Extracellular-Vesicle-Derived Biomarkers
DOI Modeling Zeta Potential for Nanoparticles in Solution: Water Flexibility Matters
DOI Red-Light-Photosensitized NO Release and Its Monitoring in Cancer Cells with Biodegradable Polymeric Nanoparticles
DOI Mixed β-γ-Cyclodextrin Branched Polymer with Multiple Photo-Chemotherapeutic Cargos

SPOKE 7 Publications

DOI Interpretation and management of premature ventricular beats in athletes: An expert opinion document of the Italian Society of Sports Cardiology (SICSPORT)

SPOKE 8 Publications

DOI ICGC ARGO precision medicine: genomic profiling-informed prediction of immunotherapy response in two patients with metastatic head and neck squamous cell carcinoma
DOI Programmed cell death 1 genetic variant and liver damage in nonalcoholic fatty liver disease
DOI Altered pathways of keratinization, extracellular matrix generation, angiogenesis, and stromal stem cells proliferation in patients with systemic sclerosis
DOI Role of the Gut–Liver Axis in the Pathobiology of Cholangiopathies: Basic and Clinical Evidence
DOI Autophagy, innate immunity, and cardiac disease
DOI Delta-radiomics in cancer immunotherapy response prediction: A systematic review
DOI Circulating metabolites improve the prediction of renal impairment in patients with type 2 diabetes
DOI Expression profiling of extramedullary acute myeloid leukemia suggests involvement of epithelial–mesenchymal transition pathways
DOI Autophagy, innate immunity, and cardiac disease
DOI Antineoplastic drugs inducing cardiac and vascular toxicity – An update
DOI Programmed cell death 1 genetic variant and liver damage in nonalcoholic fatty liver disease
DOI Noninvasive assessment of liver disease severity in patients with nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes
DOI Oesophageal varices predict complications in compensated advanced non-alcoholic fatty liver disease