Open Science Publications

Forum Nazionale sulla Medicina di Precisione

SPOKE 1 Publications

DOI Vasculopathy: a possible factor affecting hereditary angioedema
DOI The Prognostic Role of miR-375 in Head and Neck Squamous Cell Carcinoma: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis
DOI Tumor–Stroma Ratio in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis
DOI Multi-Omics Classification of Intrahepatic Cholangiocarcinoma: A Systematic Review and Meta-Analysis
DOI Correlation between Sirtuin 1 downregulation and reduced vitamin D receptor expression in patients with diabetic neuropathy
DOI A genetic variant in the potassium channel (KCNJ11) gene is associated with diabetic retinopathy in type 2 diabetes patients
DOI Atrial natriuretic peptide (ANP) modulates stress-induced autophagy in endothelial cells
DOI Vaccine-Based Immunotherapy for Oropharyngeal and Nasopharyngeal Cancers
DOI Gastroesophageal circulating tumor cell crosstalk with peripheral immune system guides CTC survival and proliferation
DOI Epigenetic modulation of RIPK3 by transglutaminase 2-dependent serotonylation of H3K4me3 affects necroptosis
DOI B cell–derived acetylcholine mitigates skin inflammation in mice through α9 nicotinic acetylcholine receptor–mediated signaling
DOI Ultrastructural studies distinguish skin diversities among Galápagos iguanas
DOI Kidney stone biology: insights from genetics
DOI Extracellular serine empowers epidermal proliferation and psoriasis-like symptoms
DOI Transglutaminase type 2-dependent crosslinking of IRF3 in dying melanoma cells
DOI Serine and one-carbon metabolism sustain non-melanoma skin cancer progression
DOI Gene expression in organoids: an expanding horizon
DOI A Novel Prognostic Biomarker in Metastatic Prostate Cancer
DOI Apoptotic cell death in disease—Current understanding of the NCCD 2023
DOI NAADP-Evoked Ca2+ Signaling Leads to Mutant Huntingtin Aggregation and Autophagy Impairment in Murine Astrocytes
DOI The STING/TBK1/IRF3/IFN type I pathway is defective in cystic fibrosis
DOI Type 2 transglutaminase in the nucleus: the new epigenetic face of a cytoplasmic enzyme
DOI Sustainable Vegetable Oil-Based Biomaterials: Synthesis and Biomedical Applications
DOI ZFP750 affects the cutaneous barrier through regulating lipid metabolism
DOI Microbiota-gut-brain axis: relationships among the vagus nerve, gut microbiota, obesity, and diabetes
DOI To metabolomics and beyond: a technological portfolio to investigate cancer metabolism
DOI Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies
DOI Hippo Pathway Activation in Aged Mesenchymal Stem Cells Contributes to the Dysregulation of Hepatic Inflammation in Aged Mice
DOI Harnessing metabolism of hepatic macrophages to aid liver regeneration
DOI The ubiquitin ligase TRIM32 promotes the autophagic response to Mycobacterium tuberculosis infection in macrophages
DOI Transglutaminase 2 and Ferroptosis: a new liaison?
DOI Study of lncRNAs expression profile in the response to biological drugs in Psoriatic Arthritis: MEG3 could be a potential genomic biomarker of therapy efficacy
DOI The obesity-autophagy-cancer axis: Mechanistic insights and therapeutic perspectives
DOI Metastatic outgrowth via the two-way interplay of autophagy and metabolism
DOI The rs11568820 Variant in the Promoter Region of Vitamin D Receptor Gene Is Associated with Clinical Remission in Rheumatoid Arthritis Patients Receiving Tumor Necrosis Factor Inhibitors
DOI Sex differences in chronic kidney disease–related complications and mortality across levels of glomerular filtration rate
DOI ER-mitochondria association negatively affects wound healing by regulating NLRP3 activation
DOI Mitophagy modulation for the treatment of cardiovascular diseases
DOI Large-scale DNA sequencing identifies rare variants associated with Systemic Lupus Erythematosus susceptibility in known risk genes
DOI The Role of TLR-2 in Lethal COVID-19 Disease Involving Medullary and Resident Lung Megakaryocyte Up-Regulation in the Microthrombosis Mechanism
DOI Monocyte bioenergetics: An immunometabolic perspective in metabolic dysfunction-associated steatohepatitis
DOI Potential Therapeutic Targets to Modulate the Endocannabinoid System in Alzheimer’s Disease
DOI Association between Controlling Nutritional Status (CONUT) Score and Body Composition, Inflammation and Frailty in Hospitalized Elderly Patients
DOI Targeting exhausted cytotoxic T cells through CTLA-4 inhibition promotes elimination of neoplastic cells in human myelofibrosis xenografts
DOI CD38 restrains the activity of extracellular cGAMP in a model of multiple myeloma
DOI Chapter Four – Settling the uncertainty about unconventional circulating tumor cells: Epithelial-to-mesenchymal transition, cell fusion and trogocytosis
DOI Decreased circulating IPA levels identify subjects with metabolic comorbidities: A multi-omics study
DOI The Role of Transglutaminase 2 in Cancer: An Update
DOI Characterization of a novel IDH2-R159H mutation in acute myeloid leukaemia: Effects on cell metabolism and differentiation
DOI Saliva-Based Biomarkers in Oral Squamous Cell Carcinoma Using OMICS Technologies: A Systematic Review
DOI Exposure to serum from exclusive heated tobacco product smokers induces mTOR activation and fibrotic features in human cardiac stromal cells
DOI Atrial natriuretic peptide (ANP) modulates stress-induced autophagy in endothelial cells
DOI Different Oxidative Stress and Inflammation Patterns of Diseased Left Anterior Descending Coronary Artery versus Internal Thoracic Artery
DOI Chromosome 9p trisomy increases stem cells clonogenic potential and fosters T-cell exhaustion in JAK2-mutant myeloproliferative neoplasms
DOI Multi-Omics Classification of Intrahepatic Cholangiocarcinoma: A Systematic Review and Meta-Analysis
DOI Targeting Isocitrate Dehydrogenase (IDH) in Solid Tumors: Current Evidence and Future Perspectives
DOI Combining gemcitabine and MSC delivering soluble TRAIL to target pancreatic adenocarcinoma and its stroma
DOI Role of AMBRA1 in mitophagy regulation: emerging evidence in aging-related diseases
DOI Thioredoxin-interacting protein (TXNIP) is a substrate of the NEDD4-like E3 ubiquitin-protein ligase WWP1 in cellular redox state regulation of acute myeloid leukemia cells
DOI Multiple antimicrobial and immune-modulating activities of cysteamine in infectious diseases
DOI Immunomodulatory effects of cysteamine and its potential use as a host-directed therapy for tuberculosis

SPOKE 2 Publications

DOI Sudden cardiac arrest prediction via deep learning electrocardiogram analysis
DOI Colorectal Cancer Outcomes of Robotic Surgery Using the Hugo™ RAS System: The First Worldwide Comparative Study of Robotic Surgery and Laparoscopy
DOI Evaluation of the impact of AI-based chatbot on orthodontic patient education: a preliminary randomised controlled trial
DOI Update on artificial intelligence against COVID-19: what we can learn for the next pandemic—a narrative review
DOI The application of augmented reality in robotic general surgery: A mini-review
DOI TSRF-Dist: a novel time series distance based on extremely randomized canonical interval forests
DOI Artificial intelligence-based models to assess the risk of malignancy on radiological imaging in patients with intraductal papillary mucinous neoplasm of the pancreas: scoping review
DOI Efficacy of MRI data harmonization in the age of machine learning. A multicenter study across 36 datasets
DOI A detailed mathematical model of the human atrial cardiomyocyte: integration of electrophysiology and cardiomechanics
DOI Artificial intelligence in endocrinology: a comprehensive review
DOI Caveolin-3 and Caveolin-1 Interaction Decreases Channel Dysfunction Due to Caveolin-3 Mutations
DOI Anatomical Study of the Application of a Galeo-Pericranial Flap in Oral Cavity Defects Reconstruction
DOI Dissecting human anatomy learning process through anatomical education with augmented reality: AEducAR 2.0, an updated interdisciplinary study
DOI Correlation-based network integration of lung RNA sequencing and DNA methylation data in chronic obstructive pulmonary disease
DOI Investigation of a potential upstream harmonization based on image appearance matching to improve radiomics features robustness: a phantom study
DOI Assessing Artificial Intelligence in Oral Cancer Diagnosis: A Systematic Review
DOI A BPMN-based Framework to Manage ERAS-inspired Pathway for Patients Undergoing Pancreatic Surgery
DOI A Migration Framework for Active BPMN Processes in Healthcare
DOI A Key Performance Indicator to Analyze Swarm Learning Performances with EHR
DOI BEAT – An Agile Design Framework for Telemedicine in Hypertension

SPOKE 3 Publications

DOI Calcium-sensitive protein MLC1 as a possible modulator of the astrocyte functional state
DOI Phosphorylation-dependent WRN-RPA interaction promotes recovery of stalled forks at secondary DNA structure
DOI The RAD52 double-ring remodels replication forks restricting fork reversal
DOI Control-FREEC viewer: a tool for the visualization and exploration of copy number variation data
DOI First-hit SETBP1 mutations cause a myeloproliferative disorder with bone marrow fibrosis
DOI Biallelic PI4KA Mutations Disrupt B-Cell Metabolism and Cause B-Cell Lymphopenia and Hypogammaglobulinemia
DOI Human Umbilical Cord-Mesenchymal Stem Cells Promote Extracellular Matrix Remodeling in Microglia
DOI Anaplastic Lymphoma Kinase (ALK) Inhibitors Enhance Phagocytosis Induced by CD47 Blockade in Sensitive and Resistant ALK-Driven Malignancies
DOI Next Generation Sequencing Identifies Subgroups of Patients With Triple Negative Primary Thrombocytosis With Different Clinical Thrombotic Outcomes
DOI Transcriptomic Profile of Human Osteoblast-like Cells Grown on Trabecular Titanium
DOI Stroma gene signature predicts responsiveness to chemotherapy in pancreatic ductal adenocarcinoma patient-derived xenograft models
DOI ARID1A Mutations in Gastric Cancer: A Review with Focus on Clinicopathological Features, Molecular Background and Diagnostic Interpretation
DOI Computational Approach for Spatially Fractionated Radiation Therapy (SFRT) and Immunological Response in Precision Radiation Therapy
DOI Mathematical modeling of the synergistic interplay of radiotherapy and immunotherapy in anti-cancer treatments
DOI Stimulation of cGAS-STING pathway as a challenge in the treatment of small cell lung cancer: a feasible strategy?
DOI Human DNA topoisomerase I poisoning causes R loop–mediated genome instability attenuated by transcription factor IIS
DOI B cell–derived acetylcholine mitigates skin inflammation in mice through α9 nicotinic acetylcholine receptor–mediated signaling
DOI miR-1297 is frequently downmodulated in flat epithelial atypia of the breast and promotes mammary
neoplastic transformation via EphrinA2 regulation
DOI CircPVT1 weakens miR-33a-5p unleashing the c-MYC/GLS1 metabolic axis in breast cancer
DOI An Optimized NGS Workflow Defines Genetically Based Prognostic Categories for Patients with Uveal Melanoma
DOI Cancer stem cells and tumor-associated macrophages as mates in tumor progression: mechanisms of crosstalk and advanced bioinformatic tools to dissect their phenotypes and interaction
DOI A Novel Tumor on Chip Mimicking the Breast Cancer Microenvironment for Dynamic Drug Screening
DOI Heightened IDO1 levels predict Bacillus Calmette-Guèrin failure in high-risk non-muscle-invasive bladder cancer patients
DOI Rationalizing the structural basis of organic-platinum hybrid complexes binding towards quadruplex-duplex hybrids through all-atom simulations
DOI Water-membrane partition and the mutant selection window of antimicrobial peptides: insights from liposome studies
DOI Evaluation of the structural models of the human reference proteome: AlphaFold2 versus ESMFold
DOI AlphaFold2 and ESMFold: A large-scale pairwise model comparison of human enzymes upon Pfam functional annotation
DOI DDGemb: predicting protein stability change upon single- and multi-point variations with embeddings and deep learning
DOI Genomic context influences translesion synthesis DNA polymerase-dependent mechanisms of micronuclei induction by G-quadruplexes
DOI C1Q+ TPP1+ macrophages promote colon cancer progression through SETD8-driven p53 methylation
DOI Deep Learning Approaches for Morphological Classification of Intestinal Organoids
DOI Designing an Intelligent Cyber-Biological System for Enhanced Analysis and Monitoring of Organoids
DOI In Vitro Models of Bacterial Biofilms: Innovative Tools to Improve Understanding and Treatment of Infections
DOI Metadynamics simulations for the investigation of drug loading on functionalized inorganic nanoparticles
DOI Gene expression in organoids: an expanding horizon
DOI Sustainable Vegetable Oil-Based Biomaterials: Synthesis and Biomedical Applications
DOI Serine and one-carbon metabolism sustain non-melanoma skin cancer progression
DOI Ca2+ signaling and cell death
DOI ANP32E drives vulnerability to ATR inhibitors by inducing R-loops-dependent Transcription Replication Conflicts in Triple Negative Breast Cancer
DOI Control-FREEC viewer: a tool for the visualization and exploration of copy number variation data
DOI First-hit SETBP1 mutations cause a myeloproliferative disorder with bone marrow fibrosis
DOI ER-mitochondria association negatively affects wound healing by regulating NLRP3 activation
DOI New Parametric 2D Curves for Modeling Prostate Shape in Magnetic Resonance Images
DOI 3D Cell Migration Chip (3DCM-Chip): A New Tool toward the Modeling of 3D Cellular Complex Systems
DOI ARID1A Mutations in Gastric Cancer: A Review with Focus on Clinicopathological Features, Molecular Background and Diagnostic Interpretation
DOI BRCA1 foci test as a predictive biomarker of olaparib response in ovarian cancer patient-derived xenograft models
DOI Overview of BH3 mimetics in ovarian cancer
DOI The endothelin-1-driven tumor-stroma feed-forward loops in high-grade serous ovarian cancer
DOI Fusion–fission–mitophagy cycling and metabolic reprogramming coordinate nerve growth factor (NGF)-dependent neuronal differentiation
DOI Megalencephalic leukoencephalopathy with subcortical cysts protein-1: A new calcium-sensitive protein functionally activated by endoplasmic reticulum calcium release and calmodulin binding in astrocytes
DOI Modeling of Magnetic Scaffolds as Drug Delivery Platforms for Tissue Engineering and Cancer Therapy
DOI Analytical Fitting of Dielectric Response of Basal Cell Carcinoma
DOI A Numerical Analysis of Microwave Hyperthermia of Deep-Seated Tumors Using Magneto-Dielectric Implants
DOI Human DNA topoisomerase I poisoning causes R loop–mediated genome instability attenuated by transcription factor IIS
DOI 3D Cell Migration Chip (3DCM-Chip): A New Tool toward the Modeling of 3D Cellular Complex Systems
DOI The miRNA Contribution in Adipocyte Maturation
DOI Anti-Tumor Immunity to Patient-Derived Breast Cancer Cells by Vaccination with Interferon-Alpha-Conditioned Dendritic Cells (IFN-DC)
DOI A nanoencapsulated oral formulation of fenretinide promotes local and metastatic breast cancer dormancy in HER2/neu transgenic mice
DOI Network Analysis of miRNA and Cytokine Landscape in Human Hematopoiesis
DOI Slow H2S-Releasing Donors and 3D Printable Arrays Cellular Models in Osteo-Differentiation of Mesenchymal Stem Cells for Personalized Therapies
DOI A 3D-Printable Cell Array for In Vitro Breast Cancer Modeling
DOI Krebs cycle derivatives, dimethyl fumarate and itaconate, control metabolic reprogramming in inflammatory human microglia cell line
DOI Functional recovery of islet β cells in human type 2 diabetes: Transcriptome signatures unveil therapeutic approaches

SPOKE 4 Publications

DOI Challenges in the diagnosis and management of AIH-PBC syndrome
DOI Real-World Impact of Olaparib Exposure in Advanced Pancreatic Cancer Patients Harboring Germline BRCA1-2 Pathogenic Variants
DOI Deep learning helps discriminate between autoimmune hepatitis and primary biliary cholangitis
DOI Dilated cardiomyopathy due to a novel combination of TTN and BAG3 genetic variants: From acute heart failure to subclinical phenotypes
DOI MYBPC3 c.2309-2A>G: exploring a founder variant in Italian hypertrophic cardiomyopathy patients
DOI Ejaculatory abstinence duration impacts semen parameters: Insights from a retrospective analysis in male infertility on 23,527 analyses
DOI Cancer stem cells and tumor-associated macrophages as mates in tumor progression: mechanisms of crosstalk and advanced bioinformatic tools to dissect their phenotypes and interaction
DOI C1Q+ TPP1+ macrophages promote colon cancer progression through SETD8-driven p53 methylation
DOI Critical review of OCT in clinical practice for the assessment of oral lesions
DOI The application of augmented reality in robotic general surgery: A mini-review
DOI Impact of primary cancer history and molecular landscape in therapy-related myeloid neoplasms
DOI Impact of Female Sex and Mild Cortisol Secretion on Coagulation Profile in Adrenal Incidentalomas
DOI Case report: Prolonged and severe hungry bone syndrome after parathyroidectomy in X-linked hypophosphatemia
DOI Reconstruction of time-activity curves in molecular radiotherapy using a Bayesian unfolding
DOI Genetic insight into lung neuroendocrine tumors: Notch and Wnt signaling pathways as potential targets
DOI Demographic-Based Personalized Left Ventricular Hypertrophy Thresholds for Hypertrophic Cardiomyopathy Diagnosis
DOI APBIO: bioactive profiling of air pollutants through inferred bioactivity signatures and prediction of novel target interactions
DOI Diagnostic accuracy and inter-reader agreement of the nacVI-RADS for bladder cancer treated with neoadjuvant chemotherapy: a prospective validation study
DOI Chronotherapy With Once-Daily Osilodrostat Improves Cortisol Rhythm, Quality of Life, and Sleep in Cushing’s Syndrome
DOI Contribution of testosterone and estradiol in sexual dimorphism of early-onset Parkinson’s disease
DOI The Prognostic Role of miR-375 in Head and Neck Squamous Cell Carcinoma: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis
DOI Risk of Neck Hematoma Following Thyroidectomy in Patients Taking Direct Oral Anticoagulants: A Propensity Score Matching Analysis from Nine High-Volume European Centers (RAGNO Study)
DOI Clinicopathologic Features of Isolated AFOP Nodules Radiologically Mimicking Malignancy in Post COVID-19 Patients: A Case Series Study
DOI Extracellular vesicles-derived miR-21 as a biomarker for early diagnosis and tumor activity in breast cancer subtypes
DOI Sex-specific immune-biological profiles in Parkinson’s disease
DOI Gastrointestinal Dysfunction Bears on the Clinical-Biological Profile of Parkinson’s Disease
DOI Gut Microbiome Modulation in Hepatocellular Carcinoma: Preventive Role in NAFLD/NASH Progression and Potential Applications in Immunotherapy-Based Strategies
DOI MiR-22/GLUT1 Axis Induces Metabolic Reprogramming and Sorafenib Resistance in Hepatocellular Carcinoma
DOI The Balance Between the Natriuretic Peptides and the Renin-Angiotensin-Aldosterone System in the Preservation of Ideal Cardiovascular Health
DOI Atrial natriuretic peptide (ANP) modulates stress-induced autophagy in endothelial cells
DOI Assessing the relationship between cardiovascular and small airway disease and acute events in COPD: The ARCADIA study protocol
DOI Value of Artificial Intelligence in Evaluating Lymph Node Metastases
DOI MiR-494 induces metabolic changes through G6pc targeting and modulates sorafenib response in hepatocellular carcinoma
DOI Personalised antiplatelet therapies for coronary artery disease: what the future holds
DOI Altered Thyroid Feedback Loop in Klinefelter Syndrome: From Infancy Through the Transition to Adulthood
DOI Prospective Validation Study of a Novel Integrated Pathway Based on Clinical Features, Magnetic Resonance Imaging Biomarkers, and MicroRNAs for Early Detection of Prostate Cancer
DOI Clinical and neurochemical correlates of the APOE genotype in early-stage Parkinson’s disease
DOI Advancing the PD-L1 CPS test in metastatic TNBC: Insights from pathologists and findings from a nationwide survey
DOI Cost analysis of archives in the pathology laboratories: from safety to management
DOI Management of Coronary Artery Disease in Older Adults: Recent Advances and Gaps in Evidence
DOI Total Bio-Based Material for Drug Delivery and Iron Chelation to Fight Cancer through Antimicrobial Activity
DOI Atrial natriuretic peptide stimulates autophagy/mitophagy and improves mitochondrial function in chronic heart failure
DOI High-risk TP53 mutations predict poor primary treatment response of patients with head and neck squamous cell carcinoma
DOI The Immune Cells in the Development of Oral Squamous Cell Carcinoma
DOI A pathogenic variant in the FLCN gene presenting with pure dementia: is autophagy at the intersection between neurodegeneration and cancer?
DOI Noncoding RNAs in Hepatocellular Carcinoma: Potential Applications in Combined Therapeutic Strategies and Promising Candidates of Treatment Response
DOI Quantitative Evaluation by Digital Pathology of Immunohistochemical Expression of CK7, CK19, and EpCAM in Advanced Stages of NASH
DOI Molecular mechanisms of naringenin modulation of mitochondrial permeability transition acting on F1FO-ATPase and counteracting saline load-induced injury in SHRSP cerebral endothelial cells
DOI Melanoma clinicopathological groups characterized and compared with dermoscopy and reflectance confocal microscopy
DOI Exploring the Link between BMI and Aggressive Histopathological Subtypes in Differentiated Thyroid Carcinoma—Insights from a Multicentre Retrospective Study
DOI UCP2, a Member of the Mitochondrial Uncoupling Proteins: An Overview from Physiological to Pathological Roles
DOI Total osteocalcin levels are independently associated with worse testicular function and a higher degree of hypothalamic–pituitary–gonadal axis activation in Klinefelter syndrome
DOI Digital pathology structure and deployment in Veneto: a proof-of-concept study
DOI High-Risk HPV CISH Detection in Cervical Biopsies with Weak and/or Focal p16 Immunohistochemical Positivity
DOI Cardiac magnetic resonance reveals biventricular impairment in Cushing’s syndrome: a multicentre case-control study
DOI Validation of ACR TI-RADS performance in transition age: results from a multicenter retrospective study by the TALENT study group
DOI Therapeutic Potential of Solenopsis invicta Venom: A Scoping Review of Its Bioactive Molecules, Biological Aspects, and Health Applications
DOI TLR4 Downregulation Identifies High-Risk HPV Infection and Integration in H-SIL and Squamous Cell Carcinomas of the Uterine Cervix
DOI TRAP1 modulates mitochondrial biogenesis via PGC-1α/TFAM signalling pathway in colorectal cancer cells
DOI What is the benefit of prophylaxis to prevent HBV reactivation in HBsAg-negative anti-HBc-positive patients? Meta-analysis and decision curve analysis
DOI Nature-inspired innovation: Alginic-kojic acid material for sustainable antibacterial and carbon dioxide fixation

SPOKE 5 Publications

DOI Lactobacillus rhamnosus GG cell-free supernatant as a novel anti-cancer adjuvant
DOI Insights into the Structural Conformations of the Tau Protein in Different Aggregation Status
DOI Readthrough approach by NV translational readthrough inducing drugs (TRIDs): a study of the possible off-target effects on natural termination codons (NTCs) on TP53 and housekeeping genes expression.
DOI Decline of gastric cancer mortality in common variable immunodeficiency in the years 2018-2022
DOI A novel complement-fixing IgM antibody targeting GPC1 as a useful immunotherapeutic strategy for the treatment of pancreatic ductal adenocarcinoma
DOI Trends and Applications in Computationally Driven Drug Repurposing
DOI In silico analysis and theratyping of an ultra-rare CFTR genotype (W57G/A234D) in primary human rectal and nasal epithelial cells
DOI BMP7 promotes cardiomyocyte regeneration in zebrafish and adult mice
DOI From Conventional to Sustainable Catalytic Approaches for Heterocycles Synthesis
DOI Genomic and functional analysis of the mucinolytic species Clostridium celatumClostridium tertium, and Paraclostridium bifermentans
DOI Multiplexed imaging to reveal tissue dendritic cell spatial localisation and function
DOI Oleuropein, a Component of Extra Virgin Olive Oil, Improves Liver Steatosis and Lobular Inflammation by Lipopolysaccharides–TLR4 Axis Downregulation
DOI Optimizing Transfection Efficiency in CAR-T Cell Manufacturing through Multiple Administrations of Lipid-Based Nanoparticles
DOI Oropharyngeal microbial ecosystem perturbations influence the risk for acute respiratory infections in common variable immunodeficiency
DOI Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity
DOI Structure-based mechanism of riboregulation of the metabolic enzyme SHMT1
DOI Targeted therapy for multiple myeloma: an overview on CD138-based strategies
DOI Estrogen-related differences in antitumor immunity and the gut microbiome contribute to sexual dimorphism of colorectal cancer
DOI The senescence journey in cancer immunoediting
DOI Changes in health-related quality of life in common variable immunodeficiency: an eight-year journey, including the COVID-19 pandemic
DOI Combining Translation Readthrough Inducing Drugs and Nonsense Mediated Decay Pathway Inhibition to Rescue of CFTRW1282X in Cystic Fibrosis Cell Model System
DOI BMP signaling promotes heart regeneration via alleviation of replication stress
DOI Anti-tumor activity of all-trans retinoic acid in gastric-cancer: gene-networks and molecular mechanisms
DOI Chemotherapy-induced neutropenia elicits metastasis formation in mice by promoting proliferation of disseminated tumor cells
DOI Protocol for isolating and culturing neonatal murine cardiomyocytes
DOI Anti-tumor activity of all-trans retinoic acid in gastric-cancer: gene-networks and molecular mechanisms
DOI Lung function trajectories in common variable immunodeficiencies: An observational retrospective multicenter study

SPOKE 6 Publications

DOI Enhanced Methanol Electro-Oxidation in Hierarchical Au-Pt Dendrites Supported on Graphene-like Substrate
DOI Dendritic Gold Nanoparticles Loaded on 3D Graphene-like Surface and Layer-by-Layer Assembly for Enhanced Glucose Biosensing
DOI Ultrafast Superradiant Scintillation from Isolated Weakly Confined Perovskite Nanocrystals
DOI Encapsulation of thyme essential oil in dendritic mesoporous silica nanoparticles: Enhanced antimycotic properties and ROS-mediated inhibition mechanism
DOI Targeted NIR-triggered doxorubicin release using carbon dots–poly(ethylene glycol)–folate conjugates for breast cancer treatment
DOI Amine-Functionalized Gellan Gum-Based Hydrogel Loaded with Adipose Stem Cell-Derived Small Extracellular Vesicles: An In Vitro Proof of Concept for Enhancing Diabetic Foot Ulcer Healing
DOI Ultra-Wideband Dielectric Mirrors via Digitally Chirped Nanoporous Silica Bragg Reflectors
DOI Building up accurate atomistic models of biofunctionalized magnetite nanoparticles from first-principles calculations
DOI The UNICA sleep HRV analysis tool: an integrated open-source tool for heart rate variability analysis during sleep
DOI A DenseNet-based Abnormal Ventricular Potentials Onset Delineation: A Feasibility Study
DOI Nanostructured Strategies for Melanoma Treatment—Part II: Targeted Topical Delivery of Curcumin via Poloxamer-Based Thermosensitive Hydrogels
DOI Nanostructured Strategies for Melanoma Treatment—Part I: Design and Optimization of Curcumin-Loaded Micelles for Enhanced Anticancer Activity
DOI Evaluation of Self-Regulating Doped Ferrite Nanoparticles with Glucose, Chitosan, and Poly-Ethylene Glycol Coatings for Hyperthermia and Dual Imaging
DOI Idarubicin-loaded chitosan nanobubbles to improve survival and decrease drug side effects in hepatocellular carcinoma
DOI Reduction of tumor burden via precise photothermal release of sirolimus by carbon nanodots in 3D plexiform neurofibroma-in-a-dish models
DOI Light-Activatable Hyaluronic Acid-Derivatives Releasing Nitric Oxide and Their Delivery in the Skin
DOI N-Doped Carbon Dot-Based Nanoconjugates with Simultaneous Generation of Nitric Oxide and Singlet Oxygen for Phototherapeutic Applications
DOI Tailored hydrothermal platforms for fluorescent Q-dots with theranostic application
DOI DNA-loaded targeted nanoparticles as a safe platform to produce exogenous proteins in tumor B cells
DOI Trans-Pd(II) complexes: A different approach for the development of promising anticancer drugs
DOI Circulating Tumor DNA: A New Research Frontier in Urological Oncology from Localized to Metastatic Disease
DOI Unveiling the drug delivery mechanism of graphene oxide dots at the atomic scale
DOI Size-Dependent Multiexciton Dynamics Governs Scintillation From Perovskite Quantum Dots
DOI Optimizing Polyethylene Glycol Coating for Stealth Nanodiamonds
DOI Partially degalactosylated xyloglucan hydrogel artificial niches enhance human spheroids derived from adipose stem cells stemness and differentiation potential
DOI The anti-glypican 1 AT101 antibody as targeting agent to effectively deliver chitosan nanobubbles to glioblastoma cells
DOI In vivo and in situ monitoring of doxorubicin pharmacokinetics with an implantable bioresorbable optical sensor
DOI Harnessing sulfur-doped carbon nanodots conjugated with IDO inhibitors act as a dual-mode breast cancer immunotherapy
DOI An in-depth NMR investigation of thermoresponsive unimer micelles loaded with the highly hydrophobic antitumor drug CA-4
DOI Real-World Outcomes and Molecular Profiling for Patients with Metastatic Castration-resistant Prostate Cancer with Lung Metastases: A Long-term Multicenter Experience
DOI Antimicrobial NIR-Responsive Hydrogels Based on Gellan Gum and Bis-MPA Polyester Dendrimers
DOI The Key Role of Wettability and Boundary Layer in Dissolution Rate Test
DOI H105A peptide eye drops promote photoreceptor survival in murine and human models of retinal degeneration
DOI Dual-Targeting Strategy to Repurpose Cetuximab with HFn Nanoconjugates for Immunotherapy of Triple-Negative Breast Cancer
DOI Metadynamics simulations for the investigation of drug loading on functionalized inorganic nanoparticles
DOI Chasing the Role of miRNAs in RCC: From Free-Circulating to Extracellular-Vesicle-Derived Biomarkers
DOI Modeling Zeta Potential for Nanoparticles in Solution: Water Flexibility Matters
DOI Red-Light-Photosensitized NO Release and Its Monitoring in Cancer Cells with Biodegradable Polymeric Nanoparticles
DOI Mixed β-γ-Cyclodextrin Branched Polymer with Multiple Photo-Chemotherapeutic Cargos
DOI Initial management approach for localized/locally advanced disease is critical to guide metastatic castration-resistant prostate cancer care
DOI Heart Rate Variability during Sleep-Related Wake Phases in REM Sleep Behavior Disorder
DOI A fluorescent probe with an ultra-rapid response to nitric oxide
DOI Vitamin C Affinity to TiO2 Nanotubes: A Computational Study by Hybrid Density Functional Theory Calculations
DOI Mechanism of RGD-conjugated nanodevice binding to its target protein integrin αVβ3 by atomistic molecular dynamics and machine learning
DOI Lung Disease Management by Iloprost-Loaded Nanoparticles to Address Hyperinflammation Associated with Cystic Fibrosis
DOI Ultrasmall Glucose-Functionalized Au-Carbon Nanohybrids: Exploiting the Warburg Effect to Image Tumors by Multimodal CT/Fluorescence Imaging
DOI The effect of polymer coating on nanoparticles’ interaction with lipid membranes studied by coarse-grained molecular dynamics simulations
DOI Nose-to-Brain Drug Delivery and Physico-Chemical Properties of Nanosystems: Analysis and Correlation Studies of Data from Scientific Literature
DOI Supramolecular red-light-photosensitized nitric oxide release with fluorescence self-reporting within biocompatible nanocarriers
DOI Organic Mixed Ionic Electronic Conductor Nanochannels for Vertical Electrochemical and Ionic Transistors
DOI Ultrafast Nanocomposite Scintillators Based on Cd-Enhanced CsPbCl3 Nanocrystals in Polymer Matrix
DOI Prognostic analysis and outcomes of metastatic pancreatic cancer patients receiving nab-paclitaxel plus gemcitabine as second or later-line treatment
DOI Androgen receptor, PARP signaling, and tumor microenvironment: the ‘perfect triad’ in prostate cancer?
DOI Spray-Coated, Magnetically Connectable Free-Standing Epidermal Electrodes for High Quality Biopotential Recordings
DOI Characterization of Sleep Structure and Autonomic Dysfunction in REM Sleep Behavior Disorder
DOI Perovskite Nanocrystals Initiate One-Step Oxygen Tolerant PET-RAFT Polymerization of Highly Loaded, Efficient Plastic Nanocomposites
DOI Resurfaced CsPbBr3 Nanocrystals Enable Free Radical Thermal Polymerization of Efficient Ultrafast Polyvinyl Styrene Nanocomposite Scintillators
DOI Cooling-Induced Order–Disorder Phase Transition in CsPbBr3 Nanocrystal Superlattices
DOI Size-Dependent Multiexciton Dynamics Governs Scintillation From Perovskite Quantum Dots
DOI Circulating Tumor DNA: A New Research Frontier in Urological Oncology from Localized to Metastatic Disease
DOI Electronic interaction-enhanced NO photorelease and photothermal conversion in N-doped carbon dot nanoconjugates
DOI Fluorescence Label-Free Doxorubicin Sensor Using Polystyrene Sulfonate as a Synthetic Receptor in Whispering Gallery Mode Microresonators
DOI Xyloglucan, alginate and k-carrageenan hydrogels on spheroids of adipose stem cells survival; preparation, mechanical characterization, morphological analysis and injectability
DOI Nitric Oxide-Photodelivering Materials with Multiple Functionalities: From Rational Design to Therapeutic Applications
DOI Lipid–Polymer Hybrid Nanoparticles in Microparticle-Based Powder: Evaluating the Potential of Methylprednisolone Delivery for Future Lung Disease Treatment via Inhalation
DOI Voltage- and Metal-assisted Chemical Etching of Micro and Nano Structures in Silicon: A Comprehensive Review
DOI Ultrafast Superradiant Scintillation from Weakly Confined CsPbBr3 Nanocrystals
DOI Charge Carrier Density in Organic Semiconductors Modulates the Effective Capacitance: A Unified View of Electrolyte Gated Organic Transistors

SPOKE 7 Publications


DOI Complementary methods for the study of interactions between eosinophils and cancer cells
DOI Benzodiazepine diazepam regulates cell surface β1-adrenergic receptor density in human monocytes
DOI A web-based scoping review assessing the influence of smoking and smoking cessation on antidiabetic drug meabolism: implications for medication efficacy
DOI Influence of quitting smoking on diabetes-related complications: A scoping review with a systematic search strategy
DOI ANCA-negative EGPA: only eosinophils without vasculitis? Insights from anti-T2 biologics
DOI Proteomic profiling of formalin-fixed paraffine-embedded tissue reveals key proteins related to lung dysfunction in idiopathic pulmonary fibrosis
DOI Expression of HOXB7 in the Lung of Patients with Idiopathic Pulmonary Fibrosis: A Proof-of-Concept Study
DOI Chlorpyrifos induces autophagy by suppressing the mTOR pathway in immortalized GnRH neurons
DOI Are we ready to use ultrasounds in the clinical assessment of depth of invasion and tumor thickness in oral squamous cell carcinoma? Results from a systematic review, meta-analysis and trial sequential analysis
DOI Insights into the Sex-Related Effects of Dietary Polyphenols and Metabolic Disruptors on Inflammatory and (Neuro) Endocrine Pathways in Obesity: The HEAL Project
DOI IL-33 stimulates the anticancer activities of eosinophils through extracellular vesicle-driven reprogramming of tumor cells

SPOKE 8 Publications



DOI Culprit or innocent bystander? The case of a new fast-moving hemoglobin J variant in a pregnant woman
DOI Long-term persistence of dysplastic features in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and arsenic trioxide
DOI CT-based radiogenomic analysis to predict high-risk colon cancer (ATTRACT): a multicentric trial
DOI Circulating tumor DNA clearance as a predictive biomarker of pathologic complete response in patients with solid tumors treated with neoadjuvant immune checkpoint inhibitors: a systematic review and meta-analysis
DOI Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in mice
DOI Diagnostic Accuracy of Radiomics in the Early Detection of Pancreatic Cancer: A Systematic Review and Qualitative Assessment Using the Methodological Radiomics Score (METRICS)
DOI Refining the link between obesity and heart failure: insights from GLP-1 receptor agonist trials and studies adopting direct adiposity measures
DOI Pooled analysis of 3,741 stool metagenomes from 18 cohorts for cross-stage and strain-level reproducible microbial biomarkers of colorectal cancer
DOI Further strategies after immune checkpoint inhibitors in relapsed/refractory Hodgkin lymphoma: salvage treatments and consolidation with transplantation, experience in daily clinical practice
DOI Prevalence and predictive risk factors of hypertensive disorders in pregnant women at high risk for gestational diabetes. The PREeclampsia in DIabetiC gestaTION (PREDICTION) study
DOI Exploring the Prognostic and Predictive Impact of Genomic Loss of Heterozygosity and Homologous Recombination Deficiency Alterations in Patients With Metastatic Colorectal Cancer
DOI SARS-CoV-2 infection does not affect the outcome of patients with relapsed/refractory large B-cell lymphoma treated with CAR T-cell therapy
DOI Long-term efficacy of immune checkpoint inhibitors for relapsed primary mediastinal B-cell lymphoma: a real-world study
DOI A constitutive interferon-high immunophenotype defines response to immunotherapy in colorectal cancer
DOI ICGC ARGO precision medicine: genomic profiling-informed prediction of immunotherapy response in two patients with metastatic head and neck squamous cell carcinoma
DOI Role of the Gut–Liver Axis in the Pathobiology of Cholangiopathies: Basic and Clinical Evidence
DOI Delta-radiomics in cancer immunotherapy response prediction: A systematic review
DOI Circulating metabolites improve the prediction of renal impairment in patients with type 2 diabetes
DOI Expression profiling of extramedullary acute myeloid leukemia suggests involvement of epithelial–mesenchymal transition pathways
DOI Autophagy, innate immunity, and cardiac disease
DOI Antineoplastic drugs inducing cardiac and vascular toxicity – An update
DOI Noninvasive assessment of liver disease severity in patients with nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes
DOI Oesophageal varices predict complications in compensated advanced non-alcoholic fatty liver disease
DOI Radiomics and deep learning models for CT pre-operative lymph node staging in pancreatic ductal adenocarcinoma: A systematic review and meta-analysis
DOI Accuracy of intermittently scanned continuous glucose monitoring during caesarean delivery in pregnant women with insulin-treated diabetes
DOI Validation in type 2 diabetes of a metabolomic signature of all-cause mortality
DOI Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity
DOI Machine-learning-guided recognition of α and β cells from label-free infrared micrographs of living human islets of Langerhans
DOI Prevalence and Determinants of Liver Disease in Relatives of Italian Patients With Advanced MASLD
DOI Navigating the landscape of liver cancer management: Study designs in clinical trials and clinical practice
DOI Glucose metabolism in B cell malignancies: a focus on glycolysis branching pathways
DOI Predicting early recurrence after resection of initially unresectable colorectal liver metastases: the role of baseline and pre-surgery clinical, radiological and molecular factors in a real-life multicentre experience
DOI Treatment of patients with BRAFV600E-mutated metastatic colorectal cancer after progression to encorafenib and cetuximab: data from a real-world nationwide dataset
DOI Risk of liver-related events in metabolic dysfunction–associated steatohepatitis (MASH) patients with fibrosis: A comparative analysis of various risk stratification criteria
DOI Serum ferritin levels can predict long-term outcomes in patients with metabolic dysfunction-associated steatotic liver disease
DOI The first MASH drug therapy on the horizon: Current perspectives of resmetirom
DOI Non-Invasive Diagnostic Tests for Portal Hypertension in Patients with HBV- and HCV-Related Cirrhosis: A Comprehensive Review
DOI Molecular and clinical presentation of UBA1-mutated myelodysplastic syndromes
DOI Advances in the pathogenesis of FLT3-mutated acute myeloid leukemia and targeted treatments
DOI Impact of PNPLA3 I148M on Clinical Outcomes in Patients With MASLD
DOI Clinical outcomes of MAFLD versus NAFLD: A meta-analysis of observational studies
DOI Preserving momentum on next-generation sequencing for head and neck squamous cell carcinoma
DOI Predicting the Risk of Adverse Neonatal Outcomes in Women With Insulin-Treated Diabetes: Is It Time for a Pregnancy-Specific Glycemic Risk Index (GRI)?
DOI Sotatercept: New drug on the horizon of pulmonary hypertension