Forum Nazionale sulla Medicina di Precisione
SPOKE 1 Publications
● DOI Vasculopathy: a possible factor affecting hereditary angioedema
● DOI The Prognostic Role of miR-375 in Head and Neck Squamous Cell Carcinoma: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis
● DOI Tumor–Stroma Ratio in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis
● DOI Multi-Omics Classification of Intrahepatic Cholangiocarcinoma: A Systematic Review and Meta-Analysis
● DOI Correlation between Sirtuin 1 downregulation and reduced vitamin D receptor expression in patients with diabetic neuropathy
● DOI A genetic variant in the potassium channel (KCNJ11) gene is associated with diabetic retinopathy in type 2 diabetes patients
● DOI Atrial natriuretic peptide (ANP) modulates stress-induced autophagy in endothelial cells
● DOI Vaccine-Based Immunotherapy for Oropharyngeal and Nasopharyngeal Cancers
● DOI Gastroesophageal circulating tumor cell crosstalk with peripheral immune system guides CTC survival and proliferation
● DOI Epigenetic modulation of RIPK3 by transglutaminase 2-dependent serotonylation of H3K4me3 affects necroptosis
● DOI B cell–derived acetylcholine mitigates skin inflammation in mice through α9 nicotinic acetylcholine receptor–mediated signaling
● DOI Ultrastructural studies distinguish skin diversities among Galápagos iguanas
● DOI Kidney stone biology: insights from genetics
● DOI Extracellular serine empowers epidermal proliferation and psoriasis-like symptoms
● DOI Transglutaminase type 2-dependent crosslinking of IRF3 in dying melanoma cells
● DOI Serine and one-carbon metabolism sustain non-melanoma skin cancer progression
● DOI Gene expression in organoids: an expanding horizon
● DOI A Novel Prognostic Biomarker in Metastatic Prostate Cancer
● DOI Apoptotic cell death in disease—Current understanding of the NCCD 2023
● DOI NAADP-Evoked Ca2+ Signaling Leads to Mutant Huntingtin Aggregation and Autophagy Impairment in Murine Astrocytes
● DOI The STING/TBK1/IRF3/IFN type I pathway is defective in cystic fibrosis
● DOI Type 2 transglutaminase in the nucleus: the new epigenetic face of a cytoplasmic enzyme
● DOI Sustainable Vegetable Oil-Based Biomaterials: Synthesis and Biomedical Applications
● DOI ZFP750 affects the cutaneous barrier through regulating lipid metabolism
● DOI Microbiota-gut-brain axis: relationships among the vagus nerve, gut microbiota, obesity, and diabetes
● DOI To metabolomics and beyond: a technological portfolio to investigate cancer metabolism
● DOI Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies
● DOI Hippo Pathway Activation in Aged Mesenchymal Stem Cells Contributes to the Dysregulation of Hepatic Inflammation in Aged Mice
● DOI Harnessing metabolism of hepatic macrophages to aid liver regeneration
● DOI The ubiquitin ligase TRIM32 promotes the autophagic response to Mycobacterium tuberculosis infection in macrophages
● DOI Transglutaminase 2 and Ferroptosis: a new liaison?
● DOI Study of lncRNAs expression profile in the response to biological drugs in Psoriatic Arthritis: MEG3 could be a potential genomic biomarker of therapy efficacy
● DOI The obesity-autophagy-cancer axis: Mechanistic insights and therapeutic perspectives
● DOI Metastatic outgrowth via the two-way interplay of autophagy and metabolism
● DOI The rs11568820 Variant in the Promoter Region of Vitamin D Receptor Gene Is Associated with Clinical Remission in Rheumatoid Arthritis Patients Receiving Tumor Necrosis Factor Inhibitors
● DOI Sex differences in chronic kidney disease–related complications and mortality across levels of glomerular filtration rate
● DOI ER-mitochondria association negatively affects wound healing by regulating NLRP3 activation
● DOI Mitophagy modulation for the treatment of cardiovascular diseases
● DOI Large-scale DNA sequencing identifies rare variants associated with Systemic Lupus Erythematosus susceptibility in known risk genes
● DOI The Role of TLR-2 in Lethal COVID-19 Disease Involving Medullary and Resident Lung Megakaryocyte Up-Regulation in the Microthrombosis Mechanism
● DOI Monocyte bioenergetics: An immunometabolic perspective in metabolic dysfunction-associated steatohepatitis
● DOI Potential Therapeutic Targets to Modulate the Endocannabinoid System in Alzheimer’s Disease
● DOI Association between Controlling Nutritional Status (CONUT) Score and Body Composition, Inflammation and Frailty in Hospitalized Elderly Patients
● DOI Targeting exhausted cytotoxic T cells through CTLA-4 inhibition promotes elimination of neoplastic cells in human myelofibrosis xenografts
● DOI CD38 restrains the activity of extracellular cGAMP in a model of multiple myeloma
● DOI Chapter Four – Settling the uncertainty about unconventional circulating tumor cells: Epithelial-to-mesenchymal transition, cell fusion and trogocytosis
● DOI Decreased circulating IPA levels identify subjects with metabolic comorbidities: A multi-omics study
● DOI The Role of Transglutaminase 2 in Cancer: An Update
● DOI Characterization of a novel IDH2-R159H mutation in acute myeloid leukaemia: Effects on cell metabolism and differentiation
● DOI Saliva-Based Biomarkers in Oral Squamous Cell Carcinoma Using OMICS Technologies: A Systematic Review
● DOI Exposure to serum from exclusive heated tobacco product smokers induces mTOR activation and fibrotic features in human cardiac stromal cells
● DOI Atrial natriuretic peptide (ANP) modulates stress-induced autophagy in endothelial cells
●DOI Different Oxidative Stress and Inflammation Patterns of Diseased Left Anterior Descending Coronary Artery versus Internal Thoracic Artery
● DOI Chromosome 9p trisomy increases stem cells clonogenic potential and fosters T-cell exhaustion in JAK2-mutant myeloproliferative neoplasms
● DOI Multi-Omics Classification of Intrahepatic Cholangiocarcinoma: A Systematic Review and Meta-Analysis
● DOI Targeting Isocitrate Dehydrogenase (IDH) in Solid Tumors: Current Evidence and Future Perspectives
● DOI Combining gemcitabine and MSC delivering soluble TRAIL to target pancreatic adenocarcinoma and its stroma
● DOI Role of AMBRA1 in mitophagy regulation: emerging evidence in aging-related diseases
● DOI Thioredoxin-interacting protein (TXNIP) is a substrate of the NEDD4-like E3 ubiquitin-protein ligase WWP1 in cellular redox state regulation of acute myeloid leukemia cells
● DOI Multiple antimicrobial and immune-modulating activities of cysteamine in infectious diseases
● DOI Immunomodulatory effects of cysteamine and its potential use as a host-directed therapy for tuberculosis
SPOKE 2 Publications
● DOI Sudden cardiac arrest prediction via deep learning electrocardiogram analysis
● DOI Colorectal Cancer Outcomes of Robotic Surgery Using the Hugo™ RAS System: The First Worldwide Comparative Study of Robotic Surgery and Laparoscopy
● DOI Evaluation of the impact of AI-based chatbot on orthodontic patient education: a preliminary randomised controlled trial
● DOI Update on artificial intelligence against COVID-19: what we can learn for the next pandemic—a narrative review
● DOI The application of augmented reality in robotic general surgery: A mini-review
● DOI TSRF-Dist: a novel time series distance based on extremely randomized canonical interval forests
● DOI Artificial intelligence-based models to assess the risk of malignancy on radiological imaging in patients with intraductal papillary mucinous neoplasm of the pancreas: scoping review
● DOI Efficacy of MRI data harmonization in the age of machine learning. A multicenter study across 36 datasets
● DOI A detailed mathematical model of the human atrial cardiomyocyte: integration of electrophysiology and cardiomechanics
● DOI Artificial intelligence in endocrinology: a comprehensive review
● DOI Caveolin-3 and Caveolin-1 Interaction Decreases Channel Dysfunction Due to Caveolin-3 Mutations
● DOI Anatomical Study of the Application of a Galeo-Pericranial Flap in Oral Cavity Defects Reconstruction
● DOI Dissecting human anatomy learning process through anatomical education with augmented reality: AEducAR 2.0, an updated interdisciplinary study
● DOI Correlation-based network integration of lung RNA sequencing and DNA methylation data in chronic obstructive pulmonary disease
● DOI Investigation of a potential upstream harmonization based on image appearance matching to improve radiomics features robustness: a phantom study
● DOI Assessing Artificial Intelligence in Oral Cancer Diagnosis: A Systematic Review
● DOI A BPMN-based Framework to Manage ERAS-inspired Pathway for Patients Undergoing Pancreatic Surgery
● DOI A Migration Framework for Active BPMN Processes in Healthcare
● DOI A Key Performance Indicator to Analyze Swarm Learning Performances with EHR
● DOI BEAT – An Agile Design Framework for Telemedicine in Hypertension
SPOKE 3 Publications
● DOI Calcium-sensitive protein MLC1 as a possible modulator of the astrocyte functional state
● DOI Phosphorylation-dependent WRN-RPA interaction promotes recovery of stalled forks at secondary DNA structure
● DOI The RAD52 double-ring remodels replication forks restricting fork reversal
● DOI Control-FREEC viewer: a tool for the visualization and exploration of copy number variation data
● DOI First-hit SETBP1 mutations cause a myeloproliferative disorder with bone marrow fibrosis
● DOI Biallelic PI4KA Mutations Disrupt B-Cell Metabolism and Cause B-Cell Lymphopenia and Hypogammaglobulinemia
● DOI Human Umbilical Cord-Mesenchymal Stem Cells Promote Extracellular Matrix Remodeling in Microglia
● DOI Anaplastic Lymphoma Kinase (ALK) Inhibitors Enhance Phagocytosis Induced by CD47 Blockade in Sensitive and Resistant ALK-Driven Malignancies
● DOI Next Generation Sequencing Identifies Subgroups of Patients With Triple Negative Primary Thrombocytosis With Different Clinical Thrombotic Outcomes
● DOI Transcriptomic Profile of Human Osteoblast-like Cells Grown on Trabecular Titanium
● DOI Stroma gene signature predicts responsiveness to chemotherapy in pancreatic ductal adenocarcinoma patient-derived xenograft models
● DOI ARID1A Mutations in Gastric Cancer: A Review with Focus on Clinicopathological Features, Molecular Background and Diagnostic Interpretation
● DOI Computational Approach for Spatially Fractionated Radiation Therapy (SFRT) and Immunological Response in Precision Radiation Therapy
● DOI Mathematical modeling of the synergistic interplay of radiotherapy and immunotherapy in anti-cancer treatments
● DOI Stimulation of cGAS-STING pathway as a challenge in the treatment of small cell lung cancer: a feasible strategy?
● DOI Human DNA topoisomerase I poisoning causes R loop–mediated genome instability attenuated by transcription factor IIS
● DOI B cell–derived acetylcholine mitigates skin inflammation in mice through α9 nicotinic acetylcholine receptor–mediated signaling
● DOI miR-1297 is frequently downmodulated in flat epithelial atypia of the breast and promotes mammary
neoplastic transformation via EphrinA2 regulation
● DOI CircPVT1 weakens miR-33a-5p unleashing the c-MYC/GLS1 metabolic axis in breast cancer
● DOI An Optimized NGS Workflow Defines Genetically Based Prognostic Categories for Patients with Uveal Melanoma
● DOI Cancer stem cells and tumor-associated macrophages as mates in tumor progression: mechanisms of crosstalk and advanced bioinformatic tools to dissect their phenotypes and interaction
● DOI A Novel Tumor on Chip Mimicking the Breast Cancer Microenvironment for Dynamic Drug Screening
● DOI Heightened IDO1 levels predict Bacillus Calmette-Guèrin failure in high-risk non-muscle-invasive bladder cancer patients
● DOI Rationalizing the structural basis of organic-platinum hybrid complexes binding towards quadruplex-duplex hybrids through all-atom simulations
● DOI Water-membrane partition and the mutant selection window of antimicrobial peptides: insights from liposome studies
● DOI Evaluation of the structural models of the human reference proteome: AlphaFold2 versus ESMFold
● DOI AlphaFold2 and ESMFold: A large-scale pairwise model comparison of human enzymes upon Pfam functional annotation
● DOI DDGemb: predicting protein stability change upon single- and multi-point variations with embeddings and deep learning
● DOI Genomic context influences translesion synthesis DNA polymerase-dependent mechanisms of micronuclei induction by G-quadruplexes
● DOI C1Q+ TPP1+ macrophages promote colon cancer progression through SETD8-driven p53 methylation
● DOI Deep Learning Approaches for Morphological Classification of Intestinal Organoids
● DOI Designing an Intelligent Cyber-Biological System for Enhanced Analysis and Monitoring of Organoids
● DOI In Vitro Models of Bacterial Biofilms: Innovative Tools to Improve Understanding and Treatment of Infections
● DOI Metadynamics simulations for the investigation of drug loading on functionalized inorganic nanoparticles
● DOI Gene expression in organoids: an expanding horizon
● DOI Sustainable Vegetable Oil-Based Biomaterials: Synthesis and Biomedical Applications
● DOI Serine and one-carbon metabolism sustain non-melanoma skin cancer progression
● DOI Ca2+ signaling and cell death
● DOI ANP32E drives vulnerability to ATR inhibitors by inducing R-loops-dependent Transcription Replication Conflicts in Triple Negative Breast Cancer
● DOI Control-FREEC viewer: a tool for the visualization and exploration of copy number variation data
● DOI First-hit SETBP1 mutations cause a myeloproliferative disorder with bone marrow fibrosis
● DOI ER-mitochondria association negatively affects wound healing by regulating NLRP3 activation
● DOI New Parametric 2D Curves for Modeling Prostate Shape in Magnetic Resonance Images
● DOI 3D Cell Migration Chip (3DCM-Chip): A New Tool toward the Modeling of 3D Cellular Complex Systems
● DOI ARID1A Mutations in Gastric Cancer: A Review with Focus on Clinicopathological Features, Molecular Background and Diagnostic Interpretation
● DOI BRCA1 foci test as a predictive biomarker of olaparib response in ovarian cancer patient-derived xenograft models
● DOI Overview of BH3 mimetics in ovarian cancer
● DOI The endothelin-1-driven tumor-stroma feed-forward loops in high-grade serous ovarian cancer
● DOI Fusion–fission–mitophagy cycling and metabolic reprogramming coordinate nerve growth factor (NGF)-dependent neuronal differentiation
● DOI Megalencephalic leukoencephalopathy with subcortical cysts protein-1: A new calcium-sensitive protein functionally activated by endoplasmic reticulum calcium release and calmodulin binding in astrocytes
● DOI Modeling of Magnetic Scaffolds as Drug Delivery Platforms for Tissue Engineering and Cancer Therapy
● DOI Analytical Fitting of Dielectric Response of Basal Cell Carcinoma
● DOI A Numerical Analysis of Microwave Hyperthermia of Deep-Seated Tumors Using Magneto-Dielectric Implants
● DOI Human DNA topoisomerase I poisoning causes R loop–mediated genome instability attenuated by transcription factor IIS
● DOI 3D Cell Migration Chip (3DCM-Chip): A New Tool toward the Modeling of 3D Cellular Complex Systems
● DOI The miRNA Contribution in Adipocyte Maturation
● DOI Anti-Tumor Immunity to Patient-Derived Breast Cancer Cells by Vaccination with Interferon-Alpha-Conditioned Dendritic Cells (IFN-DC)
● DOI A nanoencapsulated oral formulation of fenretinide promotes local and metastatic breast cancer dormancy in HER2/neu transgenic mice
● DOI Network Analysis of miRNA and Cytokine Landscape in Human Hematopoiesis
● DOI Slow H2S-Releasing Donors and 3D Printable Arrays Cellular Models in Osteo-Differentiation of Mesenchymal Stem Cells for Personalized Therapies
● DOI A 3D-Printable Cell Array for In Vitro Breast Cancer Modeling
● DOI Krebs cycle derivatives, dimethyl fumarate and itaconate, control metabolic reprogramming in inflammatory human microglia cell line
● DOI Functional recovery of islet β cells in human type 2 diabetes: Transcriptome signatures unveil therapeutic approaches
SPOKE 4 Publications
● DOI Challenges in the diagnosis and management of AIH-PBC syndrome
● DOI Real-World Impact of Olaparib Exposure in Advanced Pancreatic Cancer Patients Harboring Germline BRCA1-2 Pathogenic Variants
● DOI Deep learning helps discriminate between autoimmune hepatitis and primary biliary cholangitis
● DOI Dilated cardiomyopathy due to a novel combination of TTN and BAG3 genetic variants: From acute heart failure to subclinical phenotypes
● DOI MYBPC3 c.2309-2A>G: exploring a founder variant in Italian hypertrophic cardiomyopathy patients
● DOI Ejaculatory abstinence duration impacts semen parameters: Insights from a retrospective analysis in male infertility on 23,527 analyses
● DOI Cancer stem cells and tumor-associated macrophages as mates in tumor progression: mechanisms of crosstalk and advanced bioinformatic tools to dissect their phenotypes and interaction
● DOI C1Q+ TPP1+ macrophages promote colon cancer progression through SETD8-driven p53 methylation
● DOI Critical review of OCT in clinical practice for the assessment of oral lesions
● DOI The application of augmented reality in robotic general surgery: A mini-review
● DOI Impact of primary cancer history and molecular landscape in therapy-related myeloid neoplasms
● DOI Impact of Female Sex and Mild Cortisol Secretion on Coagulation Profile in Adrenal Incidentalomas
● DOI Case report: Prolonged and severe hungry bone syndrome after parathyroidectomy in X-linked hypophosphatemia
● DOI Reconstruction of time-activity curves in molecular radiotherapy using a Bayesian unfolding
● DOI Genetic insight into lung neuroendocrine tumors: Notch and Wnt signaling pathways as potential targets
● DOI Demographic-Based Personalized Left Ventricular Hypertrophy Thresholds for Hypertrophic Cardiomyopathy Diagnosis
● DOI APBIO: bioactive profiling of air pollutants through inferred bioactivity signatures and prediction of novel target interactions
● DOI Diagnostic accuracy and inter-reader agreement of the nacVI-RADS for bladder cancer treated with neoadjuvant chemotherapy: a prospective validation study
● DOI Chronotherapy With Once-Daily Osilodrostat Improves Cortisol Rhythm, Quality of Life, and Sleep in Cushing’s Syndrome
● DOI Contribution of testosterone and estradiol in sexual dimorphism of early-onset Parkinson’s disease
● DOI The Prognostic Role of miR-375 in Head and Neck Squamous Cell Carcinoma: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis
● DOI Risk of Neck Hematoma Following Thyroidectomy in Patients Taking Direct Oral Anticoagulants: A Propensity Score Matching Analysis from Nine High-Volume European Centers (RAGNO Study)
● DOI Clinicopathologic Features of Isolated AFOP Nodules Radiologically Mimicking Malignancy in Post COVID-19 Patients: A Case Series Study
● DOI Extracellular vesicles-derived miR-21 as a biomarker for early diagnosis and tumor activity in breast cancer subtypes
● DOI Sex-specific immune-biological profiles in Parkinson’s disease
● DOI Gastrointestinal Dysfunction Bears on the Clinical-Biological Profile of Parkinson’s Disease
● DOI Gut Microbiome Modulation in Hepatocellular Carcinoma: Preventive Role in NAFLD/NASH Progression and Potential Applications in Immunotherapy-Based Strategies
● DOI MiR-22/GLUT1 Axis Induces Metabolic Reprogramming and Sorafenib Resistance in Hepatocellular Carcinoma
● DOI The Balance Between the Natriuretic Peptides and the Renin-Angiotensin-Aldosterone System in the Preservation of Ideal Cardiovascular Health
● DOI Atrial natriuretic peptide (ANP) modulates stress-induced autophagy in endothelial cells
● DOI Assessing the relationship between cardiovascular and small airway disease and acute events in COPD: The ARCADIA study protocol
● DOI Value of Artificial Intelligence in Evaluating Lymph Node Metastases
● DOI MiR-494 induces metabolic changes through G6pc targeting and modulates sorafenib response in hepatocellular carcinoma
● DOI Personalised antiplatelet therapies for coronary artery disease: what the future holds
● DOI Altered Thyroid Feedback Loop in Klinefelter Syndrome: From Infancy Through the Transition to Adulthood
● DOI Prospective Validation Study of a Novel Integrated Pathway Based on Clinical Features, Magnetic Resonance Imaging Biomarkers, and MicroRNAs for Early Detection of Prostate Cancer
● DOI Clinical and neurochemical correlates of the APOE genotype in early-stage Parkinson’s disease
● DOI Advancing the PD-L1 CPS test in metastatic TNBC: Insights from pathologists and findings from a nationwide survey
● DOI Cost analysis of archives in the pathology laboratories: from safety to management
● DOI Management of Coronary Artery Disease in Older Adults: Recent Advances and Gaps in Evidence
● DOI Total Bio-Based Material for Drug Delivery and Iron Chelation to Fight Cancer through Antimicrobial Activity
● DOI Atrial natriuretic peptide stimulates autophagy/mitophagy and improves mitochondrial function in chronic heart failure
● DOI High-risk TP53 mutations predict poor primary treatment response of patients with head and neck squamous cell carcinoma
● DOI The Immune Cells in the Development of Oral Squamous Cell Carcinoma
● DOI A pathogenic variant in the FLCN gene presenting with pure dementia: is autophagy at the intersection between neurodegeneration and cancer?
● DOI Noncoding RNAs in Hepatocellular Carcinoma: Potential Applications in Combined Therapeutic Strategies and Promising Candidates of Treatment Response
● DOI Quantitative Evaluation by Digital Pathology of Immunohistochemical Expression of CK7, CK19, and EpCAM in Advanced Stages of NASH
● DOI Molecular mechanisms of naringenin modulation of mitochondrial permeability transition acting on F1FO-ATPase and counteracting saline load-induced injury in SHRSP cerebral endothelial cells
● DOI Melanoma clinicopathological groups characterized and compared with dermoscopy and reflectance confocal microscopy
● DOI Exploring the Link between BMI and Aggressive Histopathological Subtypes in Differentiated Thyroid Carcinoma—Insights from a Multicentre Retrospective Study
● DOI UCP2, a Member of the Mitochondrial Uncoupling Proteins: An Overview from Physiological to Pathological Roles
● DOI Total osteocalcin levels are independently associated with worse testicular function and a higher degree of hypothalamic–pituitary–gonadal axis activation in Klinefelter syndrome
● DOI Digital pathology structure and deployment in Veneto: a proof-of-concept study
● DOI High-Risk HPV CISH Detection in Cervical Biopsies with Weak and/or Focal p16 Immunohistochemical Positivity
● DOI Cardiac magnetic resonance reveals biventricular impairment in Cushing’s syndrome: a multicentre case-control study
● DOI Validation of ACR TI-RADS performance in transition age: results from a multicenter retrospective study by the TALENT study group
● DOI Therapeutic Potential of Solenopsis invicta Venom: A Scoping Review of Its Bioactive Molecules, Biological Aspects, and Health Applications
● DOI TLR4 Downregulation Identifies High-Risk HPV Infection and Integration in H-SIL and Squamous Cell Carcinomas of the Uterine Cervix
● DOI TRAP1 modulates mitochondrial biogenesis via PGC-1α/TFAM signalling pathway in colorectal cancer cells
● DOI What is the benefit of prophylaxis to prevent HBV reactivation in HBsAg-negative anti-HBc-positive patients? Meta-analysis and decision curve analysis
● DOI Nature-inspired innovation: Alginic-kojic acid material for sustainable antibacterial and carbon dioxide fixation
SPOKE 5 Publications
● DOI Lactobacillus rhamnosus GG cell-free supernatant as a novel anti-cancer adjuvant
● DOI Insights into the Structural Conformations of the Tau Protein in Different Aggregation Status
● DOI Readthrough approach by NV translational readthrough inducing drugs (TRIDs): a study of the possible off-target effects on natural termination codons (NTCs) on TP53 and housekeeping genes expression.
● DOI Decline of gastric cancer mortality in common variable immunodeficiency in the years 2018-2022
● DOI A novel complement-fixing IgM antibody targeting GPC1 as a useful immunotherapeutic strategy for the treatment of pancreatic ductal adenocarcinoma
● DOI Trends and Applications in Computationally Driven Drug Repurposing
● DOI In silico analysis and theratyping of an ultra-rare CFTR genotype (W57G/A234D) in primary human rectal and nasal epithelial cells
● DOI BMP7 promotes cardiomyocyte regeneration in zebrafish and adult mice
● DOI From Conventional to Sustainable Catalytic Approaches for Heterocycles Synthesis
● DOI Genomic and functional analysis of the mucinolytic species Clostridium celatum, Clostridium tertium, and Paraclostridium bifermentans
● DOI Multiplexed imaging to reveal tissue dendritic cell spatial localisation and function
● DOI Oleuropein, a Component of Extra Virgin Olive Oil, Improves Liver Steatosis and Lobular Inflammation by Lipopolysaccharides–TLR4 Axis Downregulation
● DOI Optimizing Transfection Efficiency in CAR-T Cell Manufacturing through Multiple Administrations of Lipid-Based Nanoparticles
● DOI Oropharyngeal microbial ecosystem perturbations influence the risk for acute respiratory infections in common variable immunodeficiency
● DOI Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity
● DOI Structure-based mechanism of riboregulation of the metabolic enzyme SHMT1
● DOI Targeted therapy for multiple myeloma: an overview on CD138-based strategies
● DOI Estrogen-related differences in antitumor immunity and the gut microbiome contribute to sexual dimorphism of colorectal cancer
● DOI The senescence journey in cancer immunoediting
● DOI Changes in health-related quality of life in common variable immunodeficiency: an eight-year journey, including the COVID-19 pandemic
● DOI Combining Translation Readthrough Inducing Drugs and Nonsense Mediated Decay Pathway Inhibition to Rescue of CFTRW1282X in Cystic Fibrosis Cell Model System
● DOI BMP signaling promotes heart regeneration via alleviation of replication stress
● DOI Anti-tumor activity of all-trans retinoic acid in gastric-cancer: gene-networks and molecular mechanisms
● DOI Chemotherapy-induced neutropenia elicits metastasis formation in mice by promoting proliferation of disseminated tumor cells
● DOI Protocol for isolating and culturing neonatal murine cardiomyocytes
● DOI Anti-tumor activity of all-trans retinoic acid in gastric-cancer: gene-networks and molecular mechanisms
●DOI Lung function trajectories in common variable immunodeficiencies: An observational retrospective multicenter study
SPOKE 6 Publications
● DOI Enhanced Methanol Electro-Oxidation in Hierarchical Au-Pt Dendrites Supported on Graphene-like Substrate
● DOI Dendritic Gold Nanoparticles Loaded on 3D Graphene-like Surface and Layer-by-Layer Assembly for Enhanced Glucose Biosensing
● DOI Ultrafast Superradiant Scintillation from Isolated Weakly Confined Perovskite Nanocrystals
● DOI Encapsulation of thyme essential oil in dendritic mesoporous silica nanoparticles: Enhanced antimycotic properties and ROS-mediated inhibition mechanism
● DOI Targeted NIR-triggered doxorubicin release using carbon dots–poly(ethylene glycol)–folate conjugates for breast cancer treatment
● DOI Amine-Functionalized Gellan Gum-Based Hydrogel Loaded with Adipose Stem Cell-Derived Small Extracellular Vesicles: An In Vitro Proof of Concept for Enhancing Diabetic Foot Ulcer Healing
● DOI Ultra-Wideband Dielectric Mirrors via Digitally Chirped Nanoporous Silica Bragg Reflectors
● DOI Building up accurate atomistic models of biofunctionalized magnetite nanoparticles from first-principles calculations
● DOI The UNICA sleep HRV analysis tool: an integrated open-source tool for heart rate variability analysis during sleep
● DOI A DenseNet-based Abnormal Ventricular Potentials Onset Delineation: A Feasibility Study
● DOI Nanostructured Strategies for Melanoma Treatment—Part II: Targeted Topical Delivery of Curcumin via Poloxamer-Based Thermosensitive Hydrogels
● DOI Nanostructured Strategies for Melanoma Treatment—Part I: Design and Optimization of Curcumin-Loaded Micelles for Enhanced Anticancer Activity
● DOI Evaluation of Self-Regulating Doped Ferrite Nanoparticles with Glucose, Chitosan, and Poly-Ethylene Glycol Coatings for Hyperthermia and Dual Imaging
● DOI Idarubicin-loaded chitosan nanobubbles to improve survival and decrease drug side effects in hepatocellular carcinoma
● DOI Reduction of tumor burden via precise photothermal release of sirolimus by carbon nanodots in 3D plexiform neurofibroma-in-a-dish models
● DOI Light-Activatable Hyaluronic Acid-Derivatives Releasing Nitric Oxide and Their Delivery in the Skin
● DOI N-Doped Carbon Dot-Based Nanoconjugates with Simultaneous Generation of Nitric Oxide and Singlet Oxygen for Phototherapeutic Applications
● DOI Tailored hydrothermal platforms for fluorescent Q-dots with theranostic application
● DOI DNA-loaded targeted nanoparticles as a safe platform to produce exogenous proteins in tumor B cells
● DOI Trans-Pd(II) complexes: A different approach for the development of promising anticancer drugs
● DOI Circulating Tumor DNA: A New Research Frontier in Urological Oncology from Localized to Metastatic Disease
● DOI Unveiling the drug delivery mechanism of graphene oxide dots at the atomic scale
● DOI Size-Dependent Multiexciton Dynamics Governs Scintillation From Perovskite Quantum Dots
● DOI Optimizing Polyethylene Glycol Coating for Stealth Nanodiamonds
● DOI Partially degalactosylated xyloglucan hydrogel artificial niches enhance human spheroids derived from adipose stem cells stemness and differentiation potential
● DOI The anti-glypican 1 AT101 antibody as targeting agent to effectively deliver chitosan nanobubbles to glioblastoma cells
● DOI In vivo and in situ monitoring of doxorubicin pharmacokinetics with an implantable bioresorbable optical sensor
● DOI Harnessing sulfur-doped carbon nanodots conjugated with IDO inhibitors act as a dual-mode breast cancer immunotherapy
● DOI An in-depth NMR investigation of thermoresponsive unimer micelles loaded with the highly hydrophobic antitumor drug CA-4
● DOI Real-World Outcomes and Molecular Profiling for Patients with Metastatic Castration-resistant Prostate Cancer with Lung Metastases: A Long-term Multicenter Experience
● DOI Antimicrobial NIR-Responsive Hydrogels Based on Gellan Gum and Bis-MPA Polyester Dendrimers
● DOI The Key Role of Wettability and Boundary Layer in Dissolution Rate Test
● DOI H105A peptide eye drops promote photoreceptor survival in murine and human models of retinal degeneration
● DOI Dual-Targeting Strategy to Repurpose Cetuximab with HFn Nanoconjugates for Immunotherapy of Triple-Negative Breast Cancer
● DOI Metadynamics simulations for the investigation of drug loading on functionalized inorganic nanoparticles
● DOI Chasing the Role of miRNAs in RCC: From Free-Circulating to Extracellular-Vesicle-Derived Biomarkers
● DOI Modeling Zeta Potential for Nanoparticles in Solution: Water Flexibility Matters
● DOI Red-Light-Photosensitized NO Release and Its Monitoring in Cancer Cells with Biodegradable Polymeric Nanoparticles
● DOI Mixed β-γ-Cyclodextrin Branched Polymer with Multiple Photo-Chemotherapeutic Cargos
● DOI Initial management approach for localized/locally advanced disease is critical to guide metastatic castration-resistant prostate cancer care
● DOI Heart Rate Variability during Sleep-Related Wake Phases in REM Sleep Behavior Disorder
● DOI A fluorescent probe with an ultra-rapid response to nitric oxide
● DOI Vitamin C Affinity to TiO2 Nanotubes: A Computational Study by Hybrid Density Functional Theory Calculations
● DOI Mechanism of RGD-conjugated nanodevice binding to its target protein integrin αVβ3 by atomistic molecular dynamics and machine learning
● DOI Lung Disease Management by Iloprost-Loaded Nanoparticles to Address Hyperinflammation Associated with Cystic Fibrosis
● DOI Ultrasmall Glucose-Functionalized Au-Carbon Nanohybrids: Exploiting the Warburg Effect to Image Tumors by Multimodal CT/Fluorescence Imaging
● DOI The effect of polymer coating on nanoparticles’ interaction with lipid membranes studied by coarse-grained molecular dynamics simulations
● DOI Nose-to-Brain Drug Delivery and Physico-Chemical Properties of Nanosystems: Analysis and Correlation Studies of Data from Scientific Literature
● DOI Supramolecular red-light-photosensitized nitric oxide release with fluorescence self-reporting within biocompatible nanocarriers
● DOI Organic Mixed Ionic Electronic Conductor Nanochannels for Vertical Electrochemical and Ionic Transistors
● DOI Ultrafast Nanocomposite Scintillators Based on Cd-Enhanced CsPbCl3 Nanocrystals in Polymer Matrix
● DOI Prognostic analysis and outcomes of metastatic pancreatic cancer patients receiving nab-paclitaxel plus gemcitabine as second or later-line treatment
● DOI Androgen receptor, PARP signaling, and tumor microenvironment: the ‘perfect triad’ in prostate cancer?
● DOI Spray-Coated, Magnetically Connectable Free-Standing Epidermal Electrodes for High Quality Biopotential Recordings
● DOI Characterization of Sleep Structure and Autonomic Dysfunction in REM Sleep Behavior Disorder
● DOI Perovskite Nanocrystals Initiate One-Step Oxygen Tolerant PET-RAFT Polymerization of Highly Loaded, Efficient Plastic Nanocomposites
● DOI Resurfaced CsPbBr3 Nanocrystals Enable Free Radical Thermal Polymerization of Efficient Ultrafast Polyvinyl Styrene Nanocomposite Scintillators
● DOI Cooling-Induced Order–Disorder Phase Transition in CsPbBr3 Nanocrystal Superlattices
● DOI Size-Dependent Multiexciton Dynamics Governs Scintillation From Perovskite Quantum Dots
● DOI Circulating Tumor DNA: A New Research Frontier in Urological Oncology from Localized to Metastatic Disease
● DOI Electronic interaction-enhanced NO photorelease and photothermal conversion in N-doped carbon dot nanoconjugates
● DOI Fluorescence Label-Free Doxorubicin Sensor Using Polystyrene Sulfonate as a Synthetic Receptor in Whispering Gallery Mode Microresonators
● DOI Xyloglucan, alginate and k-carrageenan hydrogels on spheroids of adipose stem cells survival; preparation, mechanical characterization, morphological analysis and injectability
● DOI Nitric Oxide-Photodelivering Materials with Multiple Functionalities: From Rational Design to Therapeutic Applications
● DOI Lipid–Polymer Hybrid Nanoparticles in Microparticle-Based Powder: Evaluating the Potential of Methylprednisolone Delivery for Future Lung Disease Treatment via Inhalation
● DOI Voltage- and Metal-assisted Chemical Etching of Micro and Nano Structures in Silicon: A Comprehensive Review
● DOI Ultrafast Superradiant Scintillation from Weakly Confined CsPbBr3 Nanocrystals
● DOI Charge Carrier Density in Organic Semiconductors Modulates the Effective Capacitance: A Unified View of Electrolyte Gated Organic Transistors
SPOKE 7 Publications
● DOI Complementary methods for the study of interactions between eosinophils and cancer cells
● DOI Benzodiazepine diazepam regulates cell surface β1-adrenergic receptor density in human monocytes
● DOI A web-based scoping review assessing the influence of smoking and smoking cessation on antidiabetic drug meabolism: implications for medication efficacy
● DOI Influence of quitting smoking on diabetes-related complications: A scoping review with a systematic search strategy
● DOI ANCA-negative EGPA: only eosinophils without vasculitis? Insights from anti-T2 biologics
● DOI Proteomic profiling of formalin-fixed paraffine-embedded tissue reveals key proteins related to lung dysfunction in idiopathic pulmonary fibrosis
● DOI Expression of HOXB7 in the Lung of Patients with Idiopathic Pulmonary Fibrosis: A Proof-of-Concept Study
● DOI Chlorpyrifos induces autophagy by suppressing the mTOR pathway in immortalized GnRH neurons
● DOI Are we ready to use ultrasounds in the clinical assessment of depth of invasion and tumor thickness in oral squamous cell carcinoma? Results from a systematic review, meta-analysis and trial sequential analysis
● DOI Insights into the Sex-Related Effects of Dietary Polyphenols and Metabolic Disruptors on Inflammatory and (Neuro) Endocrine Pathways in Obesity: The HEAL Project
● DOI IL-33 stimulates the anticancer activities of eosinophils through extracellular vesicle-driven reprogramming of tumor cells
SPOKE 8 Publications
● DOI Culprit or innocent bystander? The case of a new fast-moving hemoglobin J variant in a pregnant woman
● DOI Long-term persistence of dysplastic features in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and arsenic trioxide
● DOI CT-based radiogenomic analysis to predict high-risk colon cancer (ATTRACT): a multicentric trial
● DOI Circulating tumor DNA clearance as a predictive biomarker of pathologic complete response in patients with solid tumors treated with neoadjuvant immune checkpoint inhibitors: a systematic review and meta-analysis
● DOI Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in mice
● DOI Diagnostic Accuracy of Radiomics in the Early Detection of Pancreatic Cancer: A Systematic Review and Qualitative Assessment Using the Methodological Radiomics Score (METRICS)
● DOI Refining the link between obesity and heart failure: insights from GLP-1 receptor agonist trials and studies adopting direct adiposity measures
● DOI Pooled analysis of 3,741 stool metagenomes from 18 cohorts for cross-stage and strain-level reproducible microbial biomarkers of colorectal cancer
● DOI Further strategies after immune checkpoint inhibitors in relapsed/refractory Hodgkin lymphoma: salvage treatments and consolidation with transplantation, experience in daily clinical practice
● DOI Prevalence and predictive risk factors of hypertensive disorders in pregnant women at high risk for gestational diabetes. The PREeclampsia in DIabetiC gestaTION (PREDICTION) study
● DOI Exploring the Prognostic and Predictive Impact of Genomic Loss of Heterozygosity and Homologous Recombination Deficiency Alterations in Patients With Metastatic Colorectal Cancer
● DOI SARS-CoV-2 infection does not affect the outcome of patients with relapsed/refractory large B-cell lymphoma treated with CAR T-cell therapy
● DOI Long-term efficacy of immune checkpoint inhibitors for relapsed primary mediastinal B-cell lymphoma: a real-world study
● DOI A constitutive interferon-high immunophenotype defines response to immunotherapy in colorectal cancer
● DOI ICGC ARGO precision medicine: genomic profiling-informed prediction of immunotherapy response in two patients with metastatic head and neck squamous cell carcinoma
● DOI Role of the Gut–Liver Axis in the Pathobiology of Cholangiopathies: Basic and Clinical Evidence
● DOI Delta-radiomics in cancer immunotherapy response prediction: A systematic review
● DOI Circulating metabolites improve the prediction of renal impairment in patients with type 2 diabetes
● DOI Expression profiling of extramedullary acute myeloid leukemia suggests involvement of epithelial–mesenchymal transition pathways
● DOI Autophagy, innate immunity, and cardiac disease
● DOI Antineoplastic drugs inducing cardiac and vascular toxicity – An update
● DOI Noninvasive assessment of liver disease severity in patients with nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes
● DOI Oesophageal varices predict complications in compensated advanced non-alcoholic fatty liver disease
● DOI Radiomics and deep learning models for CT pre-operative lymph node staging in pancreatic ductal adenocarcinoma: A systematic review and meta-analysis
● DOI Accuracy of intermittently scanned continuous glucose monitoring during caesarean delivery in pregnant women with insulin-treated diabetes
● DOI Validation in type 2 diabetes of a metabolomic signature of all-cause mortality
● DOI Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity
● DOI Machine-learning-guided recognition of α and β cells from label-free infrared micrographs of living human islets of Langerhans
● DOI Prevalence and Determinants of Liver Disease in Relatives of Italian Patients With Advanced MASLD
● DOI Navigating the landscape of liver cancer management: Study designs in clinical trials and clinical practice
● DOI Glucose metabolism in B cell malignancies: a focus on glycolysis branching pathways
● DOI Predicting early recurrence after resection of initially unresectable colorectal liver metastases: the role of baseline and pre-surgery clinical, radiological and molecular factors in a real-life multicentre experience
● DOI Treatment of patients with BRAFV600E-mutated metastatic colorectal cancer after progression to encorafenib and cetuximab: data from a real-world nationwide dataset
● DOI Risk of liver-related events in metabolic dysfunction–associated steatohepatitis (MASH) patients with fibrosis: A comparative analysis of various risk stratification criteria
● DOI Serum ferritin levels can predict long-term outcomes in patients with metabolic dysfunction-associated steatotic liver disease
● DOI The first MASH drug therapy on the horizon: Current perspectives of resmetirom
● DOI Non-Invasive Diagnostic Tests for Portal Hypertension in Patients with HBV- and HCV-Related Cirrhosis: A Comprehensive Review
● DOI Molecular and clinical presentation of UBA1-mutated myelodysplastic syndromes
● DOI Advances in the pathogenesis of FLT3-mutated acute myeloid leukemia and targeted treatments
● DOI Impact of PNPLA3 I148M on Clinical Outcomes in Patients With MASLD
● DOI Clinical outcomes of MAFLD versus NAFLD: A meta-analysis of observational studies
● DOI Preserving momentum on next-generation sequencing for head and neck squamous cell carcinoma
● DOI Predicting the Risk of Adverse Neonatal Outcomes in Women With Insulin-Treated Diabetes: Is It Time for a Pregnancy-Specific Glycemic Risk Index (GRI)?
● DOI Sotatercept: New drug on the horizon of pulmonary hypertension
