Open Science Publications

● DOI Metabolic regulation by p53 prevents R-loop-associated genomic instability
● DOI Extracellular serine empowers epidermal proliferation and psoriasis-like symptoms
● DOI Transglutaminase type 2-dependent crosslinking of IRF3 in dying melanoma cells
● DOI Serine and one-carbon metabolism sustain non-melanoma skin cancer progression
● DOI Gene expression in organoids: an expanding horizon
● DOI A Novel Prognostic Biomarker in Metastatic Prostate Cancer
● DOI Apoptotic cell death in disease—Current understanding of the NCCD 2023
● DOI NAADP-Evoked Ca²⁺ Signaling Leads to Mutant Huntingtin Aggregation and Autophagy Impairment in Murine Astrocytes
● DOI The STING/TBK1/IRF3/IFN type I pathway is defective in cystic fibrosis
● DOI Type 2 transglutaminase in the nucleus: the new epigenetic face of a cytoplasmic enzyme
● DOI Sustainable Vegetable Oil-Based Biomaterials: Synthesis and Biomedical Applications
● DOI ZFP750 affects the cutaneous barrier through regulating lipid metabolism
● DOI Microbiota-gut-brain axis: relationships among the vagus nerve, gut microbiota, obesity, and diabetes
● DOI To metabolomics and beyond: a technological portfolio to investigate cancer metabolism
● DOI Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies
● DOI Hippo Pathway Activation in Aged Mesenchymal Stem Cells Contributes to the Dysregulation of Hepatic Inflammation in Aged Mice
● DOI Harnessing metabolism of hepatic macrophages to aid liver regeneration
● DOI The ubiquitin ligase TRIM32 promotes the autophagic response to Mycobacterium tuberculosis infection in macrophages
● DOI Programmed Cell Death Pathways in Cholangiocarcinoma: Opportunities for Targeted Therapy
● DOI Transglutaminase 2 and Ferroptosis: a new liaison?
● DOI Study of lncRNAs expression profile in the response to biological drugs in Psoriatic Arthritis: MEG3 could be a potential genomic biomarker of therapy efficacy
● DOI The obesity-autophagy-cancer axis: Mechanistic insights and therapeutic perspectives
● DOI Metastatic outgrowth via the two-way interplay of autophagy and metabolism
● DOI The rs11568820 Variant in the Promoter Region of Vitamin D Receptor Gene Is Associated with Clinical Remission in Rheumatoid Arthritis Patients Receiving Tumor Necrosis Factor Inhibitors
● DOI Sex differences in chronic kidney disease–related complications and mortality across levels of glomerular filtration rate
● DOI ER-mitochondria association negatively affects wound healing by regulating NLRP3 activation
● DOI Mitophagy modulation for the treatment of cardiovascular diseases
● DOI Large-scale DNA sequencing identifies rare variants associated with Systemic Lupus Erythematosus susceptibility in known risk genes
● DOI The Role of TLR-2 in Lethal COVID-19 Disease Involving Medullary and Resident Lung Megakaryocyte Up-Regulation in the Microthrombosis Mechanism
● DOI Monocyte bioenergetics: An immunometabolic perspective in metabolic dysfunction-associated steatohepatitis
● DOI Potential Therapeutic Targets to Modulate the Endocannabinoid System in Alzheimer’s Disease
● DOI Association between Controlling Nutritional Status (CONUT) Score and Body Composition, Inflammation and Frailty in Hospitalized Elderly Patients
● DOI Targeting exhausted cytotoxic T cells through CTLA-4 inhibition promotes elimination of neoplastic cells in human myelofibrosis xenografts
● DOI CD38 restrains the activity of extracellular cGAMP in a model of multiple myeloma
● DOI Chapter Four – Settling the uncertainty about unconventional circulating tumor cells: Epithelial-to-mesenchymal transition, cell fusion and trogocytosis
● DOI Decreased circulating IPA levels identify subjects with metabolic comorbidities: A multi-omics study
● DOI Molecular profiling of a bladder cancer with very high tumour mutational burden
● DOI The Role of Transglutaminase 2 in Cancer: An Update
● DOI Characterization of a novel IDH2-R159H mutation in acute myeloid leukaemia: Effects on cell metabolism and differentiation
● DOI Genomic and transcriptomic profiling of hepatocellular carcinoma reveals a rare molecular subtype

● DOI Artificial intelligence-based models to assess the risk of malignancy on radiological imaging in patients with intraductal papillary mucinous neoplasm of the pancreas: scoping review
● DOI Efficacy of MRI data harmonization in the age of machine learning. A multicenter study across 36 datasets
● DOI A detailed mathematical model of the human atrial cardiomyocyte: integration of electrophysiology and cardiomechanics
● DOI Artificial intelligence in endocrinology: a comprehensive review
● DOI Caveolin-3 and Caveolin-1 Interaction Decreases Channel Dysfunction Due to Caveolin-3 Mutations
● DOI Anatomical Study of the Application of a Galeo-Pericranial Flap in Oral Cavity Defects Reconstruction
● DOI Dissecting human anatomy learning process through anatomical education with augmented reality: AEducAR 2.0, an updated interdisciplinary study
● DOI Correlation-based network integration of lung RNA sequencing and DNA methylation data in chronic obstructive pulmonary disease
● DOI Investigation of a potential upstream harmonization based on image appearance matching to improve radiomics features robustness: a phantom study

● DOI Recapitulating thyroid cancer histotypes through engineering embryonic stem cells
● DOI In Vitro Models of Bacterial Biofilms: Innovative Tools to Improve Understanding and Treatment of Infections
● DOI Nanoparticles: Synthesis, Pegylation, Characterization and Study of Their Luminescence Properties
● DOI Metadynamics simulations for the investigation of drug loading on functionalized inorganic nanoparticles
● DOI Gene expression in organoids: an expanding horizon
● DOI Sustainable Vegetable Oil-Based Biomaterials: Synthesis and Biomedical Applications
● DOI Serine and one-carbon metabolism sustain non-melanoma skin cancer progression
● DOI Ca²⁺ signaling and cell death
● DOI 3D Cell Migration Chip (3DCM-Chip): A New Tool toward the Modeling of 3D Cellular Complex Systems
● DOI Novel half Salphen cobalt(iii) complexes: synthesis, DNA binding and anticancer studies
● DOI ANP32E drives vulnerability to ATR inhibitors by inducing R-loops-dependent Transcription Replication Conflicts in Triple Negative Breast Cancer

● DOI Sex hormones differentially contribute to Parkinson disease in males: A multimodal biomarker study
● DOI Assessing the relationship between cardiovascular and small airway disease and acute events in COPD: The ARCADIA study protocol
● DOI Value of Artificial Intelligence in Evaluating Lymph Node Metastases
● DOI MiR-494 induces metabolic changes through G6pc targeting and modulates sorafenib response in hepatocellular carcinoma
● DOI Personalised antiplatelet therapies for coronary artery disease: what the future holds
● DOI Altered Thyroid Feedback Loop in Klinefelter Syndrome: From Infancy Through the Transition to Adulthood
● DOI Prospective Validation Study of a Novel Integrated Pathway Based on Clinical Features, Magnetic Resonance Imaging Biomarkers, and MicroRNAs for Early Detection of Prostate Cancer
● DOI Clinical and neurochemical correlates of the APOE genotype in early-stage Parkinson’s disease
● DOI Advancing the PD-L1 CPS test in metastatic TNBC: Insights from pathologists and findings from a nationwide survey
● DOI Cost analysis of archives in the pathology laboratories: from safety to management
● DOI Management of Coronary Artery Disease in Older Adults: Recent Advances and Gaps in Evidence
● DOI Total Bio-Based Material for Drug Delivery and Iron Chelation to Fight Cancer through Antimicrobial Activity
● DOI Atrial natriuretic peptide stimulates autophagy/mitophagy and improves mitochondrial function in chronic heart failure
● DOI High-risk TP53 mutations predict poor primary treatment response of patients with head and neck squamous cell carcinoma
● DOI The Immune Cells in the Development of Oral Squamous Cell Carcinoma
● DOI A pathogenic variant in the FLCN gene presenting with pure dementia: is autophagy at the intersection between neurodegeneration and cancer?
● DOI Noncoding RNAs in Hepatocellular Carcinoma: Potential Applications in Combined Therapeutic Strategies and Promising Candidates of Treatment Response
● DOI Quantitative Evaluation by Digital Pathology of Immunohistochemical Expression of CK7, CK19, and EpCAM in Advanced Stages of NASH
● DOI Molecular mechanisms of naringenin modulation of mitochondrial permeability transition acting on F₁F_O-ATPase and counteracting saline load-induced injury in SHRSP cerebral endothelial cells
● DOI Melanoma clinicopathological groups characterized and compared with dermoscopy and reflectance confocal microscopy
● DOI Exploring the Link between BMI and Aggressive Histopathological Subtypes in Differentiated Thyroid Carcinoma—Insights from a Multicentre Retrospective Study
● DOI UCP2, a Member of the Mitochondrial Uncoupling Proteins: An Overview from Physiological to Pathological Roles
● DOI Total osteocalcin levels are independently associated with worse testicular function and a higher degree of hypothalamic–pituitary–gonadal axis activation in Klinefelter syndrome
● DOI Digital pathology structure and deployment in Veneto: a proof-of-concept study
● DOI High-Risk HPV CISH Detection in Cervical Biopsies with Weak and/or Focal p16 Immunohistochemical Positivity
● DOI Cardiac magnetic resonance reveals biventricular impairment in Cushing’s syndrome: a multicentre case-control study

● DOI Lactobacillus rhamnosus GG cell-free supernatant as a novel anti-cancer adjuvant
● DOI Insights into the Structural Conformations of the Tau Protein in Different Aggregation Status
● DOI L1077P CFTR pathogenic variant function rescue by Elexacaftor–Tezacaftor–Ivacaftor in cystic fibrosis patient-derived air–liquid interface (ALI) cultures and organoids: in vitro guided personalized therapy of non-F508del patients
● DOI Readthrough approach by NV translational readthrough inducing drugs (TRIDs): a study of the possible off-target effects on natural termination codons (NTCs) on TP53 and housekeeping genes expression.
● DOI BMP7 promotes cardiomyocyte regeneration
● DOI Decline of gastric cancer mortality in common variable immunodeficiency in the years 2018-2022
● DOI A novel complement-fixing IgM antibody targeting GPC1 as a useful immunotherapeutic strategy for the treatment of pancreatic ductal adenocarcinoma
● DOI Trends and Applications in Computationally Driven Drug Repurposing
● DOI In silico analysis and theratyping of an ultra-rare CFTR genotype (W57G/A234D) in primary human rectal and nasal epithelial cells
● DOI BMP7 promotes cardiomyocyte regeneration in zebrafish and adult mice
● DOI From Conventional to Sustainable Catalytic Approaches for Heterocycles Synthesis
● DOI Genomic and functional analysis of the mucinolytic species Clostridium celatum, Clostridium tertium, and Paraclostridium bifermentans
● DOI Multiplexed imaging to reveal tissue dendritic cell spatial localisation and function
● DOI Oleuropein, a Component of Extra Virgin Olive Oil, Improves Liver Steatosis and Lobular Inflammation by Lipopolysaccharides–TLR4 Axis Downregulation
● DOI Optimizing Transfection Efficiency in CAR-T Cell Manufacturing through Multiple Administrations of Lipid-Based Nanoparticles
● DOI Oropharyngeal microbial ecosystem perturbations influence the risk for acute respiratory infections in common variable immunodeficiency
● DOI Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity
● DOI Structure-based mechanism of riboregulation of the metabolic enzyme SHMT1
● DOI Targeted therapy for multiple myeloma: an overview on CD138-based strategies
● DOI Estrogen-related differences in antitumor immunity and the gut microbiome contribute to sexual dimorphism of colorectal cancer

● DOI Er:Y₂O₃ and Nd:Y₂O₃ Nanoparticles: Synthesis, Pegylation, Characterization and Study of Their Luminescence Properties
● DOI Metadynamics simulations for the investigation of drug loading on functionalized inorganic nanoparticles
● DOI Chasing the Role of miRNAs in RCC: From Free-Circulating to Extracellular-Vesicle-Derived Biomarkers
● DOI Modeling Zeta Potential for Nanoparticles in Solution: Water Flexibility Matters
● DOI Red-Light-Photosensitized NO Release and Its Monitoring in Cancer Cells with Biodegradable Polymeric Nanoparticles
● DOI Mixed β-γ-Cyclodextrin Branched Polymer with Multiple Photo-Chemotherapeutic Cargos
● DOI Initial management approach for localized/locally advanced disease is critical to guide metastatic castration-resistant prostate cancer care
● DOI Heart Rate Variability during Sleep-Related Wake Phases in REM Sleep Behavior Disorder
● DOI A fluorescent probe with an ultra-rapid response to nitric oxide
● DOI Vitamin C Affinity to TiO₂ Nanotubes: A Computational Study by Hybrid Density Functional Theory Calculations
● DOI Mechanism of RGD-conjugated nanodevice binding to its target protein integrin α_Vβ₃ by atomistic molecular dynamics and machine learning
● DOI Lung Disease Management by Iloprost-Loaded Nanoparticles to Address Hyperinflammation Associated with Cystic Fibrosis
● DOI Ultrasmall Glucose-Functionalized Au-Carbon Nanohybrids: Exploiting the Warburg Effect to Image Tumors by Multimodal CT/Fluorescence Imaging
● DOI The effect of polymer coating on nanoparticles’ interaction with lipid membranes studied by coarse-grained molecular dynamics simulations
● DOI Nose-to-Brain Drug Delivery and Physico-Chemical Properties of Nanosystems: Analysis and Correlation Studies of Data from Scientific Literature
● DOI Supramolecular red-light-photosensitized nitric oxide release with fluorescence self-reporting within biocompatible nanocarriers
● DOI Organic Mixed Ionic Electronic Conductor Nanochannels for Vertical Electrochemical and Ionic Transistors
● DOI Ultrafast Nanocomposite Scintillators Based on Cd-Enhanced CsPbCl₃ Nanocrystals in Polymer Matrix
● DOI Prognostic analysis and outcomes of metastatic pancreatic cancer patients receiving nab-paclitaxel plus gemcitabine as second or later-line treatment
● DOI Androgen receptor, PARP signaling, and tumor microenvironment: the ‘perfect triad’ in prostate cancer?
● DOI Spray-Coated, Magnetically Connectable Free-Standing Epidermal Electrodes for High Quality Biopotential Recordings
● DOI Characterization of Sleep Structure and Autonomic Dysfunction in REM Sleep Behavior Disorder

● DOI Interpretation and management of premature ventricular beats in athletes: An expert opinion document of the Italian Society of Sports Cardiology (SICSPORT)
● DOI Complementary methods for the study of interactions between eosinophils and cancer cells
● DOI Benzodiazepine diazepam regulates cell surface β₁-adrenergic receptor density in human monocytes
● DOI Behavioral Therapy for People With Diabetes Who Smoke: A Scoping Review
● DOI A web-based scoping review assessing the influence of smoking and smoking cessation on antidiabetic drug meabolism: implications for medication efficacy
● DOI Influence of quitting smoking on diabetes-related complications: A scoping review with a systematic search strategy
● DOI Pre-scleroderma and new opportunities for preventive medicine

● DOI ICGC ARGO precision medicine: genomic profiling-informed prediction of immunotherapy response in two patients with metastatic head and neck squamous cell carcinoma
● DOI Programmed cell death 1 genetic variant and liver damage in nonalcoholic fatty liver disease
● DOI Altered pathways of keratinization, extracellular matrix generation, angiogenesis, and stromal stem cells proliferation in patients with systemic sclerosis
● DOI Role of the Gut–Liver Axis in the Pathobiology of Cholangiopathies: Basic and Clinical Evidence
● DOI Autophagy, innate immunity, and cardiac disease
● DOI Delta-radiomics in cancer immunotherapy response prediction: A systematic review
● DOI Circulating metabolites improve the prediction of renal impairment in patients with type 2 diabetes
● DOI Expression profiling of extramedullary acute myeloid leukemia suggests involvement of epithelial–mesenchymal transition pathways
● DOI Autophagy, innate immunity, and cardiac disease
● DOI Antineoplastic drugs inducing cardiac and vascular toxicity – An update
● DOI Programmed cell death 1 genetic variant and liver damage in nonalcoholic fatty liver disease
● DOI Noninvasive assessment of liver disease severity in patients with nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes
● DOI Oesophageal varices predict complications in compensated advanced non-alcoholic fatty liver disease
● DOI Radiomics and deep learning models for CT pre-operative lymph node staging in pancreatic ductal adenocarcinoma: A systematic review and meta-analysis
● DOI Accuracy of intermittently scanned continuous glucose monitoring during caesarean delivery in pregnant women with insulin-treated diabetes
● DOI Validation in type 2 diabetes of a metabolomic signature of all-cause mortality
● DOI Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity
● DOI Machine-learning-guided recognition of α and β cells from label-free infrared micrographs of living human islets of Langerhans
● DOI Navigating the landscape of liver cancer management: Study designs in clinical trials and clinical practice
● DOI Serum ferritin levels can predict long-term outcomes in patients with metabolic dysfunction-associated steatotic liver disease
● DOI Prevalence and Determinants of Liver Disease in Relatives of Italian Patients With Advanced MASLD